PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ote100081250031
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Ocimum
Family E2F/DP
Protein Properties Length: 428aa    MW: 47808.4 Da    PI: 4.657
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ote100081250031genomeOteDB-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP81.95.3e-26101166171
                       E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                                   r+++sL llt+kf++l++++e+g+++ln +a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Ote100081250031|100081250031 101 RYDSSLSLLTKKFIALIKHAEDGELDLNMAADTL---QV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 166
                                   6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.1E-2798168IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.41E-16101164IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.9E-33101166IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.1E-24103166IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440741.05E-25181256No hitNo description
PfamPF164211.1E-23182260IPR032198E2F transcription factor, CC-MB domain
CDDcd146604.21E-32182257No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 428 aa     Download sequence    Send to blast
MVYSPTTFVL ICNAHADFNV QIGISQPFKR KNGYQNNEVE SSELTASQAY SDIANSPFRT  60
PVAKGRANCR SKATKNNRSA PSTPISSVDA PSPLTPASSC RYDSSLSLLT KKFIALIKHA  120
EDGELDLNMA ADTLQVQKRR IYDITNVLEG IGLIEKKLKN RIHWKGLDPS RPGDMDKDGT  180
LLHAEIENLS MEEKCLDERI RQMQEKLRDY SEEKNNQRWL FVTEDDIKTL PCFQNETLIA  240
IKAPHGTTLE VPDPDEEKFD EMNGVDNSTN FPIASSSGSH ENLAVQGSPL AHAPPQIETH  300
TRESHEINSV YDSSQEYPGG MTKIIPSNID NDADYWLLSD ADISITDMWK TDSGVEWNDV  360
NMLQEELEMA GISTPRAHVP SSGVDNEQPR SCKKYPDVGT LLENLQNSLQ RINLQKHGLC  420
DPDVCELM
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-2596169276PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011094221.10.0transcription factor E2FA
SwissprotQ9FNY01e-108E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A4D9AXF60.0A0A4D9AXF6_SALSN; Uncharacterized protein
STRINGMigut.J00719.1.p1e-171(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]