PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016503156.1
Common NameE2FB
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 449aa    MW: 49569.1 Da    PI: 4.3833
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016503156.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.77.2e-27128193171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l+++ e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  XP_016503156.1 128 RYDSSLGLLTKKFINLIKHPEDGMLDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 193
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.1E-29126195IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467856.12E-17128191IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.5E-33128193IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.9E-24130193IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.82E-46204310No hitNo description
SuperFamilySSF1440748.37E-33206310No hitNo description
PfamPF164211.7E-32209308IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 449 aa     Download sequence    Send to blast
MQPQQQQQQP SLKRQLQFSS IKPAFGDYHR FSTDPVHCSS QEPPAGIVVK TPPLKRKSAA  60
ANYGQGVGDQ NPVSEYANVN SPVQTPMSGK AGNTQKIPKT SKARSASQAV ASNAGSPSGN  120
VTPVGPCRYD SSLGLLTKKF INLIKHPEDG MLDLNKAADT LEVQKRRIYD ITNVLEGIGL  180
IEKKLKNRIQ WKGLDVSKPG EADESIASLQ GDVENLTIEE RRLDDQIRET QERLRDLSED  240
EDNQRWLFVT EDDIKSLPCF QNKTLIAIKA PHGTTLEVPD PDDAVDYPQR RYRIALRSTM  300
GPIDVYLVSQ FEEKFEEINA IEATPSVPST SGLNENATMT LATEENREVD IGMDEKENQG  360
VGSDVGTSED LMTGIMKIVP DVDNEADYWL LSDADVSITD MWRTESAIDW NELDVIQEDF  420
SIANVSTPRS ETPPTNTTEV PSAANTTGF
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-25123194274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHE6539230.0HE653923.1 Nicotiana tabacum mRNA for transcription factor E2FB (E2FB gene), cultivar Samsun nn.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016501039.10.0PREDICTED: transcription factor E2FB-like
RefseqXP_016503156.10.0PREDICTED: transcription factor E2FB-like
SwissprotQ9FV711e-152E2FB_ARATH; Transcription factor E2FB
TrEMBLM5BCF30.0M5BCF3_TOBAC; Transcription factor E2FB
STRINGXP_009802122.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-152E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Lukhovitskaya NI, et al.
    An RNA virus-encoded zinc-finger protein acts as a plant transcription factor and induces a regulator of cell size and proliferation in two tobacco species.
    Plant Cell, 2013. 25(3): p. 960-73
    [PMID:23482855]
  3. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  4. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]