PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016497357.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 348aa    MW: 38616 Da    PI: 4.255
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016497357.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP871.4e-272691171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  XP_016497357.1 26 RYDSSLGLLTKKFINLIKHAEDGMLDLNQAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 91
                    6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.0E-302493IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.6E-342691IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.16E-172689IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023198.6E-252891IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440741.54E-33105208No hitNo description
PfamPF164212.6E-33107206IPR032198E2F transcription factor, CC-MB domain
CDDcd146601.20E-46107208No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 348 aa     Download sequence    Send to blast
KSNKSGPPTP VSNVGSPSPL TPANCRYDSS LGLLTKKFIN LIKHAEDGML DLNQAADTLE  60
VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GVDASRPGEV DNDAAILKAE TESLSMEERR  120
LDDQVRELQE KLRDMSEDED NQKWLFVTEE DLKSLPCFQN ETLIAVKAPH GTTLEVPDPD  180
EAVDYSQRRY RIILRSTMGP IDVYLVSQFE EKFEEMNSVE PSMAIPVASS SGSKDNPAME  240
RSTLSNSVTE NEVQTQNVDQ LSSDLGTSQD YGGGMVKVVP SDVDNDADYW LLSDAHVSIT  300
NMWEADPAVE WDGENLLHEF GIADLGTPRA HTPSAVTDVP TPMNVPPR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-261992274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC2397387e-75AC239738.5 Solanum lycopersicum strain Heinz 1706 chromosome 1 clone hba-240p19 map 1, complete sequence.
GenBankHG9754407e-75HG975440.1 Solanum pennellii chromosome ch01, complete genome.
GenBankHG9755137e-75HG975513.1 Solanum lycopersicum chromosome ch01, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016497357.10.0PREDICTED: transcription factor E2FA-like, partial
SwissprotQ9FNY01e-138E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A1S4C7X90.0A0A1S4C7X9_TOBAC; transcription factor E2FA-like
STRINGXP_009602094.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-142E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]