PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016456149.1
Common NameERF168
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family ERF
Protein Properties Length: 129aa    MW: 14530.7 Da    PI: 4.4939
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016456149.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
             AP2   2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtae 40 
                     +y GVr+++ +g+++AeIrdp  +g  +r +lg++ t+e
                     699******.**********95454..**********87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541711.18E-1094129IPR016177DNA-binding domain
Gene3DG3DSA:3.30.730.102.4E-1694129IPR001471AP2/ERF domain
PROSITE profilePS5103216.09494129IPR001471AP2/ERF domain
CDDcd000181.53E-1494129No hitNo description
SMARTSM003801.4E-494129IPR001471AP2/ERF domain
PfamPF008479.9E-794129IPR001471AP2/ERF domain
PRINTSPR003676.0E-795106IPR001471AP2/ERF domain
PRINTSPR003676.0E-7118129IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 129 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtActs as a transcriptional activator and may be involved in disease resistance pathways. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways mediated by ethylene, that seems to depend on a protein kinase cascade, and to be influenced by methyl-jasmonate. {ECO:0000269|PubMed:10652129, ECO:0000269|PubMed:10792818, ECO:0000269|PubMed:7756828, ECO:0000269|Ref.2}.
UniProtActs as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. {ECO:0000269|PubMed:11950980}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by ethephon (ethylene-releasing compound) in buds and to a lower extent in leaves. Strongly induced by cycloheximide and mechanical stimuli. Wounding leads to a both local and systemic expression, independently of ethylene, and through a de-novo-protein-synthesis-independent regulation. Wound induction is reduced by methyl-jasmonate. Induction by purified xylanase from Trichoderma viride (TvX) and another elicitor from Phytophthora infestans (PiE), that appears to be mediated by both protein kinases and protein phosphatases. {ECO:0000269|PubMed:10652129, ECO:0000269|PubMed:12090623, ECO:0000269|PubMed:7756828, ECO:0000269|Ref.2}.
UniProtINDUCTION: Strongly induced by wounding. Induced by Pseudomonas syringae tomato (both virulent and avirulent avrRpt2 strains), independently of PAD4. Also induced by methyl jasmonate (MeJA) independently of JAR1, but seems to not be affected by ethylene. Induction by salicylic acid (SA) is controlled by growth and/or developmental conditions, and seems to be more efficient and independent of PAD4 in older plants. {ECO:0000269|PubMed:11950980, ECO:0000269|PubMed:12068110}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB8281510.0AB828151.1 Nicotiana tabacum ERF168 mRNA for ethylene response factor 168, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016456149.14e-92PREDICTED: ethylene-responsive transcription factor 13-like
SwissprotQ404792e-16ERF2_TOBAC; Ethylene-responsive transcription factor 2
SwissprotQ8L9K12e-16ERF99_ARATH; Ethylene-responsive transcription factor 13
TrEMBLA0A1S3YVG39e-91A0A1S3YVG3_TOBAC; ethylene-responsive transcription factor 13-like
STRINGXP_009592010.12e-83(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G44840.18e-18ethylene-responsive element binding factor 13
Publications ? help Back to Top
  1. Nakano T,Nishiuchi T,Suzuki K,Fujimura T,Shinshi H
    Studies on transcriptional regulation of endogenous genes by ERF2 transcription factor in tobacco cells.
    Plant Cell Physiol., 2006. 47(4): p. 554-8
  2. Maimbo M,Ohnishi K,Hikichi Y,Yoshioka H,Kiba A
    Induction of a small heat shock protein and its functional roles in Nicotiana plants in the defense response against Ralstonia solanacearum.
    Plant Physiol., 2007. 145(4): p. 1588-99
  3. Shoji T,Kajikawa M,Hashimoto T
    Clustered transcription factor genes regulate nicotine biosynthesis in tobacco.
    Plant Cell, 2010. 22(10): p. 3390-409
  4. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229