PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009800726.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 469aa    MW: 52054.9 Da    PI: 4.408
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009800726.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.51.9e-27149214171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  XP_009800726.1 149 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 214
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.2E-29147216IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.62E-17149212IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.2E-35149214IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.6E-24151214IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146608.95E-43225331No hitNo description
SuperFamilySSF1440746.28E-30227331No hitNo description
PfamPF164211.4E-29230329IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 469 aa     Download sequence    Send to blast
MQQPHHQQRE LPFTSSKPPL GDYHRFSTDP LQQPEAILVK STVISSIGFE LNFDFTSVEF  60
FICSYAWKSP FLPLKRKSET TNYKQGVGAQ ITDSGYADVS SPMQTPISGK VGKAQKVPRT  120
SKARSASQAA TSNLGSPSGN NATPVGPCRY DSSLGLLTKK FINLIKHAED GILDLNKAAD  180
TLEVQKRRIY DITNVLEGIG LIEKKLKNRI QWKGLDVSRP GEVDDSVTSL QAEVENMTIE  240
ERRLNEQTRE MQERLTDLCE DENNQRWLLV TEDDIKSLPC LQNETLIAIK APHGTTLEVP  300
DPDEAVDYPQ RRYRIVLRST MGPIDVYLVS QFEEKFEEIN AVEAPSAMPS TSGFNENETA  360
TLPTEESGGV DGRIDEKENQ SVCADVGTSQ DFASGIMKIV SDVDNEEDYW LLSDADVSIT  420
DIWRADSVLD WNELNVIHED YSIANVSTPR AQTPPSSTTE LPSANTTGS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-26144215274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0253470.0AB025347.1 Nicotiana tabacum mRNA for transcription factor, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009800726.10.0PREDICTED: transcription factor E2FB-like isoform X1
SwissprotQ9FV711e-143E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A1U7YFJ20.0A0A1U7YFJ2_NICSY; transcription factor E2FB-like isoform X1
STRINGXP_009800726.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-146E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]