PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009789426.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 484aa    MW: 52670.8 Da    PI: 4.6406
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009789426.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.32.3e-27162227171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  XP_009789426.1 162 RYDSSLGLLTKKFINLIKHAEDGMLDLNQAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 227
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.4E-29160229IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.6E-34162227IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.54E-17162225IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.4E-24164227IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.97E-33241344No hitNo description
PfamPF164211.4E-32243342IPR032198E2F transcription factor, CC-MB domain
CDDcd146601.15E-47243344No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 484 aa     Download sequence    Send to blast
MSFDTKMTGP DAPPTGVAAP PAAQSSSAAV NGGGRSQISQ PIRRYLPFAS MRPPFVSPED  60
YHRFGGVDSR IGSPTLQPDA IVVKSPALKR KGGMGYKAVE SCDWTANPGY SDVANSPLGT  120
PVSGKGGRAN GRSRATKSNK SGPPTPVSNV GSPSPLTPAS CRYDSSLGLL TKKFINLIKH  180
AEDGMLDLNQ AADTLEVQKR RIYDITNVLE GIGLIEKKLK NRIQWKGVDA SRPGEVDNDA  240
AILKAETESL SIEERRLDDR VRELQEKLRD MSEDEDNQKW LFVTEEDIKS LPCFQNETLI  300
AVKAPHGTTL EVPDPDEAVD YPQRRYRIIL RSTMGPIDVY LVSQFEEKFE EMNSVEPSMA  360
IPVASSSGSK DNPAMERSTL SNNVTENEGQ TQNVDQLSSD LGTSQDYGGG MMKVVPSDVD  420
NDADYWLLSD AHVSITNMWE ADPAVEWDGE NLLHEFGIAD LGTPRAHTPS AVTDVPTPMN  480
VPPR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A8e-26155228274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00661PBMTransfer from Pp3c1_6880Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC2397381e-74AC239738.5 Solanum lycopersicum strain Heinz 1706 chromosome 1 clone hba-240p19 map 1, complete sequence.
GenBankHG9754401e-74HG975440.1 Solanum pennellii chromosome ch01, complete genome.
GenBankHG9755131e-74HG975513.1 Solanum lycopersicum chromosome ch01, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009789426.10.0PREDICTED: transcription factor E2FA isoform X1
SwissprotQ9FNY01e-160E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A1U7XIF60.0A0A1U7XIF6_NICSY; transcription factor E2FA isoform X1
STRINGXP_009789426.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-156E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]