PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Niben101Scf01372g01005.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 497aa    MW: 54540.1 Da    PI: 4.61
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Niben101Scf01372g01005.1genomeBTI-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP788.8e-25181240771
                   E2F_TDP   7 rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                               +llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Niben101Scf01372g01005.1 181 GLLTKKFINLIKHAEDGMLDLNQAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 240
                               69**************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM013723.4E-27175240IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.27E-15180238IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.108.0E-26181242IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.7E-22181240IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440743.14E-32254357No hitNo description
PfamPF164214.9E-32256355IPR032198E2F transcription factor, CC-MB domain
CDDcd146602.55E-46256357No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 497 aa     Download sequence    Send to blast
MSFDTNMTGP DAPPTGVAAP PPAQSSSAAV NGGGRNQISQ PIKRYLPFAS MRPPFVSPED  60
YHRFGGVDSR IGSPTVQPDA IVVKSPALKR KGGMGYKAVE SSDWTANPGY SDVANSPLGT  120
PVSGKGGRAN GRSKATKSNK SGPPTPVSNV GEAWFSFSSY TCKLPLRQFI GYLMIFCPWI  180
GLLTKKFINL IKHAEDGMLD LNQAADTLEV QKRRIYDITN VLEGIGLIEK KLKNRIQWKG  240
VDASRPGEVD NDAAILKAET ESLSMEERRL DDRVRELQEK LRDMSEDEDD QKWLFVTEED  300
IKSLPCFQNE TLIAVKAPHG TTLEVPDPDE AVDYPQRRYR IILRSTMGPI DVYLVSQFEE  360
KFEEMNSVEP SMAIPVASSS GSKDNPAMER STLSNNVTEN EGQTQNVDQL SSDLGASQDY  420
SGGMMKVVPS DVDNDADYWL LSDAHVSITN MWEADPAVEW DGENLLHEFG ITDLGTPRAH  480
TPSAVTDVPT PMNVPPR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-221802411274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009789426.10.0PREDICTED: transcription factor E2FA isoform X1
SwissprotQ9FNY01e-147E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A1U7XIF60.0A0A1U7XIF6_NICSY; transcription factor E2FA isoform X1
STRINGXP_009789426.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-144E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]