PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Medtr1g105110.1
Common NameMTR_1g105110
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
Family E2F/DP
Protein Properties Length: 464aa    MW: 50907 Da    PI: 4.6541
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Medtr1g105110.1genomeMtView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP81.57.4e-26142207171
          E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                      r+++sL+llt+kf++ll+++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+i wkg
  Medtr1g105110.1 142 RYDSSLGLLTKKFIHLLKRAEDGILDLNKAAETL---QV--QKRRIYDITNVLEGIGLIEKNIKNRIYWKG 207
                      6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.5E-27139209IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.99E-17142205IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-32142207IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.9E-24144207IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440742.12E-33220324No hitNo description
CDDcd146601.42E-48220324No hitNo description
PfamPF164211.7E-33223322IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 464 aa     Download sequence    Send to blast
MSANAGPSDR GSPMPTGAQI RPPLKRHLAF VSTKPPFAPT DEYHTFAAVD SRKVADHVNE  60
AVIVRSPVIK RKNGMNESEG DSQKSSNSPG YNAMNSPFKT PLSAKGGRAN KSRASKEGKS  120
CPPTPISNAG SPSPLTPAGS CRYDSSLGLL TKKFIHLLKR AEDGILDLNK AAETLQVQKR  180
RIYDITNVLE GIGLIEKNIK NRIYWKGIES STPGNVDGDI SLLKSEVDNL SLEEQRLDDQ  240
IREMQERLRG LSEDENNQKF LFVTEEDIKG LPCFQNETLI AIKAPHGTTL EVPDPEEAVD  300
ELQRRYRIIL RSTMGPIDVY LISQFEEKFE EINGAEPPAS FPLASSSESN EQQATEMVPA  360
ECSGKELEPQ ALLSSQTYSD LNVSQEFAGG MMKIVPSDAD NDADYWLLSD AEVSITDMWR  420
TDSNVDWSGV DMLHPDFEML SRPQTPSPGL AEAPSTVANP NQR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A7e-24137208274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mtr.175830.0root| stem
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapMedtr1g105110.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0930465e-61BT093046.1 Soybean clone JCVI-FLGm-15I8 unknown mRNA.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_003592452.20.0transcription factor E2FA isoform X2
SwissprotQ9FNY01e-166E2FA_ARATH; Transcription factor E2FA
TrEMBLG7IE330.0G7IE33_MEDTR; E2F transcription factor
STRINGAES627030.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-170E2F transcription factor 3
Publications ? help Back to Top
  1. Young ND, et al.
    The Medicago genome provides insight into the evolution of rhizobial symbioses.
    Nature, 2011. 480(7378): p. 520-4
    [PMID:22089132]
  2. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]