PlantRegMap
Plant Transcription Factor Database
PlantTFDB
v5.0
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Mapoly0113s0037.1.p
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Marchantiophyta; Marchantiopsida; Marchantiidae; Marchantiales; Marchantiaceae; Marchantia
Family E2F/DP
Protein Properties Length: 515aa    MW: 56490.7 Da    PI: 5.7797
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Mapoly0113s0037.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.61.9e-27188253171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                          r+++sL+llt+kf++l++++++g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Mapoly0113s0037.1.p 188 RYDSSLGLLTKKFIDLIKQADDGVLDLNKAADTL---NV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 253
                          6899******************************...**..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.9E-29184254IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.0E-34188253IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.63E-17188251IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023196.5E-25190253IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146602.97E-48264369No hitNo description
SuperFamilySSF1440743.66E-30267369No hitNo description
PfamPF164215.0E-32269368IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 515 aa     Download sequence    Send to blast
MVDVAAREGK TFQASVKHPM PLRRSNSGTR AAFRPHHGNS AGHPPQQQSS MYPSSHSYAL  60
AEEYHRFHEA GAALDSQGAS ASLSHPDLTV NRFSDSGRLQ SLGSSVSSQD VKGRRKSVKN  120
DQEMEVSGWS SGNGFGGVEA SPHSTPVTKR GSRAKLVRQL KNDPHTPGGH PGIGSPASNA  180
PTPSSTCRYD SSLGLLTKKF IDLIKQADDG VLDLNKAADT LNVQKRRIYD ITNVLEGIGL  240
IEKKLKNRIR WKGLGVLRPG EGNDDAAALQ AEIDELLAAE RRMDERISEM RERLRSLSEN  300
EANKQWLYVT EEDIKNLPCF QNETLLAIKA PHGTTLEVPD PDETVEYPHR RYQILLRSNM  360
GPIDVYLVSR FQEKFEEVNH AQQPMDTAEG DAGMQPPYVA NTVMDAMPDG ERLADTGTGT  420
HHDVPSPHSD PESPHDFVHG IMRIMPAEVN TDSDYWLLSD AGVGLTDMWR SDPSNSMWSN  480
VVKLNSTEFG LGDDESPHPQ TPPSNSAPEV EPMT*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-25183255275PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024368555.11e-175transcription factor E2FA-like isoform X2
RefseqXP_024368556.11e-175transcription factor E2FA-like isoform X2
SwissprotQ9FV711e-113E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A2R6WBS20.0A0A2R6WBS2_MARPO; Uncharacterized protein
STRINGPP1S22_60V6.11e-174(Physcomitrella patens)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-108E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]