PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000606400
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family HSF
Protein Properties Length: 456aa    MW: 50948.1 Da    PI: 6.426
Description HSF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000606400genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind91.31.1e-281032342102
                    HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHT.TEEE---SSBTTTT...................... CS
   HSF_DNA-bind   2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmY.gFkkvkdeekksks...................... 74 
                    Fl+k+++++e ++l+++isw + g+sfvv+d+ ef++ +Lp+ Fkh+nf+SFvRQLn+Y g  ++    +k  +                      
  MDP0000606400 103 FLSKTFDLVEXPSLDSIISWGSGGRSFVVWDPLEFSRFILPRNFKHNNFSSFVRQLNTYvGILQIGGFYEK--Nifpseyvlergvrqvefglpsk 196
                    9**********************************************************633333333322..23466677899999999999999 PP

                    ..........XTTSEEEEESXXXXXXXXXXXXXXXXXX CS
   HSF_DNA-bind  75 ..........kekiweFkhksFkkgkkellekikrkks 102
                              +++ weF+++ F+kgk++ll++i+r+ks
  MDP0000606400 197 sviiqgfrkvDTDKWEFANEAFQKGKRHLLKRIQRRKS 234
                    888877765449************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM004155.9E-4299232IPR000232Heat shock factor (HSF)-type, DNA-binding
SuperFamilySSF467852.54E-2699168IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.0E-32100161IPR011991Winged helix-turn-helix DNA-binding domain
PRINTSPR000568.1E-11103126IPR000232Heat shock factor (HSF)-type, DNA-binding
PfamPF004474.9E-26103232IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000568.1E-11141153IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000568.1E-11154166IPR000232Heat shock factor (HSF)-type, DNA-binding
SuperFamilySSF467852.54E-26199232IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.0E-32202232IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009408Biological Processresponse to heat
GO:0010200Biological Processresponse to chitin
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 456 aa     Download sequence    Send to blast
MSPKDESHPK SPPTSAEFDP ESIGLSEFRP QVSAPLLGSQ PIPSFTSPVM EFEAFSSVNP  60
LGAFDFXEKV SIPTSSMGGG GAEDVVVPPQ PLECLQDTPV PPFLSKTFDL VEXPSLDSII  120
SWGSGGRSFV VWDPLEFSRF ILPRNFKHNN FSSFVRQLNT YVGILQIGGF YEKNIFPSEY  180
VLERGVRQVE FGLPSKSVII QGFRKVDTDK WEFANEAFQK GKRHLLKRIQ RRKSPQSLQV  240
GSFTGPSAEA GKSGVEGEIE TLRKERSXLM QEVXELQQQQ RGTVDHMKVV NQRLQSAEQR  300
QKQMVSFLTK MLQNPAFVAR LQQKTGQKDI GSSRVRRKFV KHQQHELSKS DSYMEGQIVK  360
YQPAWRNQTI SSTAPDSYPV PFEQSPHYPS QVTTGKLGLD AESTAFQFVD AALDELAITQ  420
GFXETPEQEG EGASSMVTED PFFKREECSK PTTRG*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2ldu_A6e-1710023217120Heat shock factor protein 1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1225231LKRIQRR
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress response. Activated by DREB2A under heat stress. {ECO:0000269|PubMed:17999647, ECO:0000269|PubMed:18261981}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By heat stress. {ECO:0000269|PubMed:17999647, ECO:0000269|PubMed:18261981}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028948183.10.0heat stress transcription factor A-3-like isoform X2
RefseqXP_028948184.10.0heat stress transcription factor A-3-like isoform X2
SwissprotQ8GYY11e-88HSFA3_ARATH; Heat stress transcription factor A-3
TrEMBLA0A498IJD10.0A0A498IJD1_MALDO; Uncharacterized protein
STRINGXP_008360559.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF87823038
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G03720.12e-83heat shock transcription factor A3
Publications ? help Back to Top
  1. Jung HS, et al.
    Subset of heat-shock transcription factors required for the early response of Arabidopsis to excess light.
    Proc. Natl. Acad. Sci. U.S.A., 2013. 110(35): p. 14474-9
    [PMID:23918368]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Nie S,Yue H,Xing D
    A Potential Role for Mitochondrial Produced Reactive Oxygen Species in Salicylic Acid-Mediated Plant Acquired Thermotolerance.
    Plant Physiol., 2016.
    [PMID:26099269]
  4. Hu Z, et al.
    Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis.
    Plant J., 2015. 84(6): p. 1178-91
    [PMID:26576681]
  5. Song C,Chung WS,Lim CO
    Overexpression of Heat Shock Factor Gene HsfA3 Increases Galactinol Levels and Oxidative Stress Tolerance in Arabidopsis.
    Mol. Cells, 2016. 39(6): p. 477-83
    [PMID:27109422]
  6. Kim GD,Cho YH,Lee BH,Yoo SD
    STABILIZED1 Modulates Pre-mRNA Splicing for Thermotolerance.
    Plant Physiol., 2017. 173(4): p. 2370-2382
    [PMID:28223317]
  7. Song C,Lee J,Kim T,Hong JC,Lim CO
    VOZ1, a transcriptional repressor of DREB2C, mediates heat stress responses in Arabidopsis.
    Planta, 2018. 247(6): p. 1439-1448
    [PMID:29536220]