PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000232265
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family E2F/DP
Protein Properties Length: 385aa    MW: 42718.6 Da    PI: 4.7494
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000232265genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.54e-2740105171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                    r+++sL+llt+kf+ l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  MDP0000232265  40 RYDSSLGLLTKKFIXLIKRAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 105
                    6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.5E-2937107IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.09E-1640103IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-3340105IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.8E-2442105IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.63E-48118222No hitNo description
SuperFamilySSF1440742.88E-33118222No hitNo description
PfamPF164212.2E-32121220IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 385 aa     Download sequence    Send to blast
MSTKGGRVNN RSKASKGGRS GPQTPVSNVG SPSTPAGSCR YDSSLGLLTK KFIXLIKRAE  60
DGILDLNKAA ETLEVQKRRI YDITNVLEGI GLIEKKLKNR IRWKGFDASM PGELDGDLSI  120
LQAEVENLSL QERRLDDRIR EMQEKLRDLS EDENNRKWLF VTEDDIKGLP CFHNETLIAI  180
KAPHGTTLEV PDPDEAVDYL QRRYRIILXS TMGPIDVYLV SQFDEKFEDV HGAEPPVSCP  240
MASGSGSSEH PITEVVTVES SGKEIEPWLQ QAHHTCSDLN ASQEFAGGMM KIVPSDVDVQ  300
HKMCIFICLY DDIGKAVQNI NDADYWLLSD AEVSITDMWR TDSGVGWNGT DILHADFGVT  360
DVSTPRPQTP PSRVVEVPSH AVNFA
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-2432105273PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.232830.0bud| leaf
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008387063.20.0transcription factor E2FA
SwissprotQ9FNY01e-144E2FA_ARATH; Transcription factor E2FA
TrEMBLM5W8E60.0M5W8E6_PRUPE; Uncharacterized protein
STRINGXP_008387063.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-149E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]