PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000187830
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family E2F/DP
Protein Properties Length: 459aa    MW: 50562.1 Da    PI: 5.3395
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000187830genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP77.89.9e-25157216771
        E2F_TDP   7 rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                    +llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  MDP0000187830 157 GLLTKKFINLIKRAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 216
                    68**************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
ProDomPD0423520.005148238No hitNo description
SMARTSM013724.6E-28151216IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.5E-22157216IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.08E-15157217IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.1E-25157218IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF164211.8E-22224314IPR032198E2F transcription factor, CC-MB domain
SuperFamilySSF1440741.23E-24229316No hitNo description
CDDcd146602.22E-36229316No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 459 aa     Download sequence    Send to blast
MSGFARAPNR QAPPATAANG GGGGSQILPP LRRHLAFEST KPQPFPPDNY HRFXGGPRRA  60
GDQEPEAILV RSPVISYSXS LTSKVVLLKI YCKLVQLTQK DNNEVGYSDW TSSPGNTNVI  120
QSPLQTPVSA KGGXVNNRSK ASKGGXSGPQ TPVSIVGLLT KKFINLIKRA EDGILDLNKA  180
AETLEVQKRR IYDITNVLEG IGLIEKKLKN RIRWKGFDAS MPGELDGDLS ILQAEVENLS  240
LQEXRLDDRI RWLFVTEDDI KGLPCFHNET LIAIKAPHGT TLEVPDPDEA VDYPQRRYRI  300
ILRSTMGPID VYLVSQFEEK FEDVHGAEPP VNFPIASGSG SNEHXTTEVV TVESSGKEIE  360
PWLQQVHHTC SDMNASQEFA GGMMKIVPSD VDNDADYWLL SDAEVSITDM WRTDSGVGWN  420
GTDILHADFG VTDVXTSRPQ TPPSRVVEVP SHAVNFTQR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-211562161273PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.232831e-137bud| leaf
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028947953.10.0transcription factor E2FA-like
SwissprotQ9FNY01e-140E2FA_ARATH; Transcription factor E2FA
TrEMBLM5W8E60.0M5W8E6_PRUPE; Uncharacterized protein
STRINGXP_009349217.10.0(Pyrus x bretschneideri)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.21e-140E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]