PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lus10029421
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum
Family E2F/DP
Protein Properties Length: 505aa    MW: 55236.9 Da    PI: 4.8149
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Lus10029421genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP83.91.3e-26150215171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf++l++ +e+gi++ln++a++L   +v  ++RRiYDi+NVLe+ +liek+ kn+irwkg
  Lus10029421 150 RYDSSLGLLTKKFVNLIKVAEDGIIDLNKAAETL---EV--QKRRIYDITNVLEGTGLIEKTLKNRIRWKG 215
                  6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.5E-27148216IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.0E-33150215IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467858.16E-17150213IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023194.7E-23152215IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440742.46E-33229332No hitNo description
CDDcd146603.86E-50229332No hitNo description
PfamPF164211.0E-34231330IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 505 aa     Download sequence    Send to blast
MSGGSPAASS SPQPPPPAVT SAPSSSGPIP PPMRRHLAFV SMKPPFVAPD DYHRFSTPPA  60
SSKVADRDAE AIVVRSPAFK RKLKLDDSGI DSTKWTTNTG HTDPSNSPFQ TPTKGGRTYK  120
PKSTKANKAL PQTPVSNPGS PSTLTPAGTR YDSSLGLLTK KFVNLIKVAE DGIIDLNKAA  180
ETLEVQKRRI YDITNVLEGT GLIEKTLKNR IRWKGVGGSD SGNVDGNASL LQAEIERLSL  240
EEQNLDNQIR EMSERLRNLS EDENNQKWLF VTEDDVKNLP CFQNQTLIAI KAPHGTTLEV  300
PDPDEAVDYA QRRYRIVLRS TMGPIDVYLV SQFEENFEEA IDTGPSTSVA HASSSSSSVN  360
PQVEMVSTQG TQNAVEPQLQ PPIQDDQHMF SDFNSTQEFV GGMMKIVPSD ADNETDYWLL  420
SDAADISITD MWKADGMLAD FYPSPSTPPR NVSPTQLTQS LGGHFNLALH SFLLLLQLML  480
IGWLNMNMLQ VDFEIADVQT PRPT*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-24138217275PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapLus10029421
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017629499.10.0PREDICTED: transcription factor E2FA-like
SwissprotQ9FNY01e-158E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2P5Y1W50.0A0A2P5Y1W5_GOSBA; Uncharacterized protein
STRINGLus100294210.0(Linum usitatissimum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-151E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]