PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lus10021298
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum
Family E2F/DP
Protein Properties Length: 493aa    MW: 54687.6 Da    PI: 4.9818
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Lus10021298genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.63.7e-27173237170
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 
                  r+++sL+llt+kf++l++ +e+gi++ln++a++L   dv  ++RRiYDi+NVLe+++liek+ kn+irwk
  Lus10021298 173 RYDSSLGLLTKKFVNLIKDAEDGIIDLNKAAETL---DV--QKRRIYDITNVLEGIGLIEKTLKNRIRWK 237
                  6899******************************...**..****************************8 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.109.5E-28170239IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.45E-17173236IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.7E-33173238IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.0E-24175237IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.97E-32251355No hitNo description
CDDcd146603.23E-47252355No hitNo description
PfamPF164213.9E-33254353IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 493 aa     Download sequence    Send to blast
MSDGAPASSH PPLPSAPSSG PILPPPRRHL AFVSMKPPFV APDDYHRFNS PAVSKVADQE  60
AEAIVVRAPV TLKRKLDDNG IESSKWTSSP GKTDASSSPY HTPVSAKGRT NNKPKSTKGN  120
KSVPRVPMLN PGETLQLSLC VLVFFLPSTF EIVWFSYLVC CSPSTLTPAG SCRYDSSLGL  180
LTKKFVNLIK DAEDGIIDLN KAAETLDVQK RRIYDITNVL EGIGLIEKTL KNRIRWKSVD  240
SSNSGNPDGN YSLLQAEIKK LSLEEQNLDN QIREMQERIR SFSEDENNQK WLFVTEDDIK  300
SLPCFMNETL IAIKAPHGTT MEVPDPDEAV DYPQRRYRII LRSTMGPIDV YLVSQFEENY  360
EEANDAGPSS VANASSSSSS VNPQMEMFPK QGTQNAVEPP PVQDLHHMFS DLNPSEEFVR  420
GMMKIVPTDA DNELDYWLRS DIADVSITDM WRTDSSFPEF YPSPSTPPRP AQFGMADVHT  480
PRPQTPPSRV VE*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-22168239274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapLus10021298
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012074348.10.0transcription factor E2FA
SwissprotQ9FNY01e-146E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A067KIS90.0A0A067KIS9_JATCU; Uncharacterized protein
STRINGLus100212980.0(Linum usitatissimum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-143E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]