PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lus10016972
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum
Family E2F/DP
Protein Properties Length: 473aa    MW: 52219.5 Da    PI: 4.9089
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Lus10016972genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP87.41e-27145210171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf++l++ +e+gi++ln++a++L   dv  ++RRiYDi+NVLe+++liek+ kn+irwkg
  Lus10016972 145 RYDSSLGLLTKKFVNLIKDAEDGIIDLNKAAETL---DV--QKRRIYDITNVLEGIGLIEKTLKNRIRWKG 210
                  6899******************************...**..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.7E-29142212IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-34145210IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.34E-17145208IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.6E-24147210IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440748.63E-33223327No hitNo description
CDDcd146609.84E-49224327No hitNo description
PfamPF164217.0E-34226325IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 473 aa     Download sequence    Send to blast
MSEGAPASSH PPLPSAPSSG PILPPPGRHL AFVSMKPPFV APDDYHRFTS PAASKVADRE  60
AEAIVVGSPV TLKRKLDDNG IESSKWTSSP GKTDASSSTY HTPVSAKGGR TNNKPKSTKG  120
NKSVPRMPML NPGSPSTLTP AGSCRYDSSL GLLTKKFVNL IKDAEDGIID LNKAAETLDV  180
QKRRIYDITN VLEGIGLIEK TLKNRIRWKG VDSSNSGNAD GNYSLLQAEI EKLSLEEQNL  240
DNQIREMQER IRNFSEDENN QKWLFVTEDD IKSLPCFMNE TLIAIKAPHG TTMEVPDPDE  300
AVDYPQRRYR IILRSTMGPI DVYLVSQFEE NLEEANDAGP SSVANASSSC SSVNPQMEMF  360
ATQRTQNAVE PPPVQDVHHM FTDLNPSEDF VRGMMKIFPT DADNELDYWL RSDVADVSIT  420
DMWRTDSSFP DFYPSPSTPP RPLTWNKIQA EFGMADVHTP RPQTPPSRIN VE*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-23132211274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapLus10016972
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012074348.10.0transcription factor E2FA
SwissprotQ9FNY01e-151E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A067KIS90.0A0A067KIS9_JATCU; Uncharacterized protein
STRINGLus100169720.0(Linum usitatissimum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-146E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]