PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lus10013321
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum
Family E2F/DP
Protein Properties Length: 435aa    MW: 47668.8 Da    PI: 4.5626
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Lus10013321genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP29.31.5e-09155201145
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse..dvknkrRR 45 
                  r+++sL+llt+kf++l++++e+g+++ln++a++L +e  +   + RR
  Lus10013321 155 RYDSSLGLLTKKFINLIKQAEDGMLDLNKAADTLEAEveNLAIEERR 201
                  6899******************************5556644446666 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.106.7E-9152201IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.7E-4155210IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.2E-6157202IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.71E-30186299No hitNo description
CDDcd146601.13E-45186299No hitNo description
PfamPF164212.6E-29188297IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 435 aa     Download sequence    Send to blast
MEPNSQPPTG PTQPSPPPPT QLQIDAASSP SSTALKRQLF LSSVKPPFSP TGDYHRFGPD  60
PRRAADQEPE GIVVRTPPLK RKSDAPEHGV ESSGWNTSSA HTDVVNTPIQ TPVSVKGGKA  120
PKASRLSRSK KSASKNANAN ISSPGNNLTP TGPCRYDSSL GLLTKKFINL IKQAEDGMLD  180
LNKAADTLEA EVENLAIEER RLDERIRHFG ALKSYGRDMQ ERLRDLSEDE NNQKWLFVTE  240
DDIKNIPCFQ NETLIAIKAP HGTTLEVPDP EEAADYPQRR YKIVLRSTMG PIDVYLVSQF  300
EEKFEEIHGV EPPPPPSYPS SSSLNENHAT ASVAIENRGK DIENAEQDLN PPQDYFSGIM  360
KIVPTDVDSA ADYWLLSDAG VSITDMWGTD PGFEWDEFGT LHDDYAMENV SIPQPQTPPP  420
NPTEPPSAAN TTPQ*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5tuv_B3e-1618829913111Transcription factor E2F5
5tuv_E3e-1618829913111Transcription factor E2F5
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapLus10013321
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021628243.10.0transcription factor E2FB-like isoform X2
SwissprotQ9FV711e-116E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A067KKC20.0A0A067KKC2_JATCU; Uncharacterized protein
TrEMBLA0A2C9VY820.0A0A2C9VY82_MANES; Uncharacterized protein
STRINGLus100133210.0(Linum usitatissimum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-103E2F transcription factor 3
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]