PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lus10012707
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum
Family C2H2
Protein Properties Length: 483aa    MW: 55733.7 Da    PI: 7.5084
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Lus10012707genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H211.80.00075240262123
                  EEETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                  y C+ C    +rk++L+rH+r++
  Lus10012707 240 YFCEFCLNFMKRKEQLQRHMRKC 262
                  78*******************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541602.01E-2391207IPR016197Chromo domain-like
Gene3DG3DSA:2.30.30.2705.0E-3794167No hitNo description
PfamPF117179.4E-2197155IPR025995RNA binding activity-knot of a chromodomain
CDDcd000246.74E-7110155No hitNo description
SMARTSM002987.6E-5111170IPR000953Chromo/chromo shadow domain
Gene3DG3DSA:2.30.30.2705.0E-37201251No hitNo description
PROSITE profilePS5172675.647206477IPR002717Histone acetyltransferase domain, MYST-type
SuperFamilySSF557291.45E-111207478IPR016181Acyl-CoA N-acyltransferase
Gene3DG3DSA:3.40.630.304.4E-73265408IPR016181Acyl-CoA N-acyltransferase
PfamPF018533.9E-84267444IPR002717Histone acetyltransferase domain, MYST-type
CDDcd043015.95E-4318376No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006281Biological ProcessDNA repair
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010224Biological Processresponse to UV-B
GO:2000028Biological Processregulation of photoperiodism, flowering
GO:0005634Cellular Componentnucleus
GO:0043995Molecular Functionhistone acetyltransferase activity (H4-K5 specific)
Sequence ? help Back to Top
Protein Sequence    Length: 483 aa     Download sequence    Send to blast
MNRSKLKASP INGPKIVTAD SYSQLPSPLL QFQGQNTMGS IDTPPRTDNA ASVPACTNGN  60
DSIVEEKILE GMPSLADTTA RPETEAPRKR KSSLLPLEVG TRVMCRWRDG KYHPVKVIER  120
RKVSYSDPND YEYYVHYTEF NRRLDEWVKL EQLDLESVEA VVDEKVEDKV TSLKMTRHQK  180
RKIDETHTEG HEELDAASLR EHEEFTKVKN IATIELGRYE IETWYFSPFP PEYNDCLKLY  240
FCEFCLNFMK RKEQLQRHMR KCDLKHPPGD EIYRSGTLSM FEVDGKKNKV YGQNLCYLAK  300
LFLDHKTLYY DVDLFLFYVL CECDDRGCHM VGYFSKEKHS EDSYNLACIL TLPPYQRKGY  360
GKFLIAFSYE LSKKEGKVGT PERPLSDLGL LSYRGYWTRV LLDILKKHKG NISIKELSDM  420
TAIRAEDILT TLQSLELIQY RKGQHVICAD PKVLDRHLKA AGRGGLDVDV SKLIWTPYKE  480
QG*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4dnc_A1e-1182024811282Histone acetyltransferase KAT8
4dnc_B1e-1182024811282Histone acetyltransferase KAT8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtHistone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269|PubMed:17877703, ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:22170978, ECO:0000269|PubMed:23273925}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapLus10012707
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269|PubMed:22170978}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006434100.10.0histone acetyltransferase of the MYST family 1
SwissprotQ9FLF70.0MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBLA0A067GZD90.0A0A067GZD9_CITSI; Histone acetyltransferase
TrEMBLA0A2H5NND30.0A0A2H5NND3_CITUN; Histone acetyltransferase
TrEMBLV4T7A20.0V4T7A2_9ROSI; Histone acetyltransferase
STRINGLus100127070.0(Linum usitatissimum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF70661011
Publications ? help Back to Top
  1. Latrasse D, et al.
    The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.
    BMC Plant Biol., 2008. 8: p. 121
    [PMID:19040736]
  2. Campi M,D'Andrea L,Emiliani J,Casati P
    Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA.
    Plant Physiol., 2012. 158(2): p. 981-95
    [PMID:22170978]
  3. Bari A,Orazova S,Ivashchenko A
    miR156- and miR171-binding sites in the protein-coding sequences of several plant genes.
    Biomed Res Int, 2013. 2013: p. 307145
    [PMID:23936788]
  4. Xu Y, et al.
    Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
    Nucleic Acids Res., 2014. 42(17): p. 10960-74
    [PMID:25183522]
  5. Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB
    3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana.
    J Mol Model, 2016. 22(11): p. 256
    [PMID:27709438]
  6. Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P
    HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1179
    [PMID:28740501]