PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lus10004217
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum
Family E2F/DP
Protein Properties Length: 451aa    MW: 49935.1 Da    PI: 5.0044
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Lus10004217genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.11.1e-26118183171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf++l++ +e+gi++ln++a++L   +v  ++RRiYDi+NVLe+ +liek+ kn+irwkg
  Lus10004217 118 RYDSSLGLLTKKFVNLIKVAEDGIIDLNKAAETL---EV--QKRRIYDITNVLEGTGLIEKTLKNRIRWKG 183
                  6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.109.8E-28115184IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467857.07E-17118181IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.0E-33118183IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.9E-23120183IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.53E-50194300No hitNo description
SuperFamilySSF1440743.4E-33197300No hitNo description
PfamPF164211.1E-34199298IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 451 aa     Download sequence    Send to blast
MRRHLAFVSM MPPFVAPDDY HRFSTPPASS KVADRDAEAI VVRSPAFKRK LKLDDTGIDS  60
TKWTTNAGHT DPSSSPFQTP TKGGRTYKPK STKANKALPQ TPVSNPGSPS TLTPSGTRYD  120
SSLGLLTKKF VNLIKVAEDG IIDLNKAAET LEVQKRRIYD ITNVLEGTGL IEKTLKNRIR  180
WKGVGGSDSG NVDNNASLLQ AEIERLSLEE QNLDNQIREM SERLRNLSED ENNQKWLFLT  240
EDDIKNLPCF QNQTLIAIKA PHGTTLEVPD PDEAVDYAQR RYRIILRSTM GPIDVYLVSQ  300
FEENFEEAID TGPSTSVDHA SSSSSSVNPH MVSTQGTQKA VEPQPQPSPQ PPVQDDHHMF  360
SDFNSSQELV GGMMKIVPSD ADNETDYWLL SDAADISITD MWKADGMLAD FYPSPSTPPR  420
PVSPTQLTQF SISTFRCIVF SLMLQLMLTV *
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-24106185275PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapLus10004217
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHQ8865184e-40HQ886518.1 Linum usitatissimum clone GMU2AYZ01AXZVR microsatellite sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015898822.10.0transcription factor E2FA isoform X2
SwissprotQ9FNY01e-155E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2P5Y1W50.0A0A2P5Y1W5_GOSBA; Uncharacterized protein
STRINGLus100042170.0(Linum usitatissimum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-153E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]