PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lsa019433
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca
Family TCP
Protein Properties Length: 560aa    MW: 62014.6 Da    PI: 6.4175
Description TCP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PUT-187a-Lactuca_sativa-29277PU_refplantGDBView CDS
gnl|UG|Lsa#S58693749PU_unrefUnigeneView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1TCP113.72.5e-35202310289
        TCP   2 agkkdrhskihTkvggRdRRvRlsaecaarfFdLqdeLGfdkdsktieWLlqqakpaikeltgt..........ssssasec....eaesssssasnsss 87 
                +g+kdrhsk++T++g+RdRRvRlsa++a++f+d+qd+LG+d++sk+++WL+++ak+ai+el+++          +++++s +    e   ++  ++ns++
  Lsa019433 202 TGRKDRHSKVCTAKGPRDRRVRLSAHTAIQFYDVQDRLGYDRPSKAVDWLIKKAKAAIDELAELpawkptattaTTTPNSTSiadfE---QNPDQQNSNH 298
                79**************************************************************88777666653333322222221...1111111111 PP

        TCP  88 g..........k 89 
                +          +
  Lsa019433 299 HqlshfeqhpdD 310
                122223322220 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF036345.0E-34202308IPR005333Transcription factor, TCP
PROSITE profilePS5136934.295204262IPR017887Transcription factor TCP subgroup
Sequence ? help Back to Top
Protein Sequence    Length: 560 aa     Download sequence    Send to blast
MEFDLELSVN GGVRVEXVEF DYVFSFFMLI LKKLEQEEVV HHRKGVILDP QRNHHHLHLY  60
QQLLNSRQEE KEEDQEIQIG FHGIPSKSSS VFNKIDEIPP PDNXFLHGGL GGPARQPPRP  120
QKKRPYLPSS VDQLTQEGEE YAPRLPEKMG ESYQYHNQQL QQQQQQQQQQ ASGSSRLGLR  180
GAGGGGGGEI VEVQGGHIVR STGRKDRHSK VCTAKGPRDR RVRLSAHTAI QFYDVQDRLG  240
YDRPSKAVDW LIKKAKAAID ELAELPAWKP TATTATTTPN STSIADFEQN PDQQNSNHHQ  300
LSHFEQHPDD SIVDNQMGNS QNSSFLPPSL DSDSIADTIK SFFPMGASTN PGNNTSSGMQ  360
FHQSFPPQDL LSRTSSRSQD LRLSLQSFQD PILQNHHHHH QQNEQGNNNN SNIFFDGSGW  420
SDNQPGGFQR MVAWGGVGGG DAVSAGFVFS SQPSPSTPFL QPLFGQTTNN QLFNNSQRGP  480
LQSSNAPSFR AWIDPPPPFT GVAIDQHPTL AFHHPSSMSG FASGLGGFSG FRIPARIQGE  540
EEEHDGISDK PSSASSDSRH
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5zkt_A3e-20209262154Putative transcription factor PCF6
5zkt_B3e-20209262154Putative transcription factor PCF6
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor playing a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164) (PubMed:12931144, PubMed:17307931). Required during early steps of embryogenesis (PubMed:15634699). Participates in ovule develpment (PubMed:25378179). Activates LOX2 expression by binding to the 5'-GGACCA-3' motif found in its promoter (PubMed:18816164). {ECO:0000269|PubMed:12931144, ECO:0000269|PubMed:15634699, ECO:0000269|PubMed:17307931, ECO:0000269|PubMed:18816164, ECO:0000269|PubMed:25378179}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by the miRNA miR-JAW/miR319 (PubMed:12931144, PubMed:18816164). {ECO:0000269|PubMed:12931144, ECO:0000269|PubMed:18816164}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023771332.10.0transcription factor TCP4-like isoform X1
SwissprotQ8LPR51e-97TCP4_ARATH; Transcription factor TCP4
TrEMBLA0A103XLV20.0A0A103XLV2_CYNCS; Transcription factor, TCP (Fragment)
STRINGXP_009604314.11e-128(Nicotiana tomentosiformis)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G15030.32e-46TCP family protein
Publications ? help Back to Top
  1. Schommer C, et al.
    Control of jasmonate biosynthesis and senescence by miR319 targets.
    PLoS Biol., 2008. 6(9): p. e230
    [PMID:18816164]
  2. Ju Y, et al.
    Arabidopsis JINGUBANG Is a Negative Regulator of Pollen Germination That Prevents Pollination in Moist Environments.
    Plant Cell, 2016. 28(9): p. 2131-2146
    [PMID:27468890]
  3. Challa KR,Aggarwal P,Nath U
    Activation of YUCCA5 by the Transcription Factor TCP4 Integrates Developmental and Environmental Signals to Promote Hypocotyl Elongation in Arabidopsis.
    Plant Cell, 2016. 28(9): p. 2117-2130
    [PMID:27597774]
  4. Alvarez JP,Furumizu C,Efroni I,Eshed Y,Bowman JL
    Active suppression of a leaf meristem orchestrates determinate leaf growth.
    Elife, 2017.
    [PMID:27710768]
  5. Li J, et al.
    RABBIT EARS regulates the transcription of TCP4 during petal development in Arabidopsis.
    J. Exp. Bot., 2016. 67(22): p. 6473-6480
    [PMID:27838638]
  6. Sun X, et al.
    Activation of secondary cell wall biosynthesis by miR319-targeted TCP4 transcription factor.
    Plant Biotechnol. J., 2017. 15(10): p. 1284-1294
    [PMID:28233945]
  7. Kubota A, et al.
    TCP4-dependent induction of CONSTANS transcription requires GIGANTEA in photoperiodic flowering in Arabidopsis.
    PLoS Genet., 2017. 13(6): p. e1006856
    [PMID:28628608]
  8. Koyama T,Sato F,Ohme-Takagi M
    Roles of miR319 and TCP Transcription Factors in Leaf Development.
    Plant Physiol., 2017. 175(2): p. 874-885
    [PMID:28842549]
  9. Bresso EG,Chorostecki U,Rodriguez RE,Palatnik JF,Schommer C
    Spatial Control of Gene Expression by miR319-Regulated TCP Transcription Factors in Leaf Development.
    Plant Physiol., 2018. 176(2): p. 1694-1708
    [PMID:29133375]
  10. Vadde BVL,Challa KR,Nath U
    The TCP4 transcription factor regulates trichome cell differentiation by directly activating GLABROUS INFLORESCENCE STEMS in Arabidopsis thaliana.
    Plant J., 2018. 93(2): p. 259-269
    [PMID:29165850]
  11. Challa KR,Rath M,Nath U
    The CIN-TCP transcription factors promote commitment to differentiation in Arabidopsis leaf pavement cells via both auxin-dependent and independent pathways.
    PLoS Genet., 2019. 15(2): p. e1007988
    [PMID:30742619]