PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lsa011966
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca
Family TCP
Protein Properties Length: 335aa    MW: 36999.8 Da    PI: 7.0809
Description TCP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Lsa#S58678293PU_refUnigeneView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1TCP112.27.3e-35732112108
        TCP   2 agkkdrhskihTkvggRdRRvRlsaecaarfFdLqdeLGfdkdsktieWLlqqakpaikeltgt...................ssssa...sec..eaes 77 
                +g+kdrhsk++T++g+RdRRvRl a++a++f+d+qd+LG+d++sk+++WL+++ak+ai+el ++                       +   ++c  + ++
  Lsa011966  73 TGRKDRHSKVCTAKGPRDRRVRLAAHTAIQFYDVQDRLGYDRPSKAVDWLIKKAKTAIDELDELpawkptsttaatnstsilnF---EqhpNDCiiD-NQ 168
                79**************************************************************88877766555444444431...0223455421.11 PP

        TCP  78 ssssasnsssg............................kaaksaakskksqksaasal 108
                 s        +                            +        + +++s++sa 
  Lsa011966 169 MS--------NaqnssflppsldsdsiadtiksffpmggS--------STPHNSNSSAM 211
                11........011222234555555555663333333320........22222222222 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF036343.4E-3073198IPR005333Transcription factor, TCP
PROSITE profilePS5136933.03375133IPR017887Transcription factor TCP subgroup
Sequence ? help Back to Top
Protein Sequence    Length: 335 aa     Download sequence    Send to blast
VQPLLPPQKK RSYLFSLVED ENATDEKMGG SYQYEHQELC RRQSPVGGSS RLGLRNSGGE  60
IVEVHGGHIV RSTGRKDRHS KVCTAKGPRD RRVRLAAHTA IQFYDVQDRL GYDRPSKAVD  120
WLIKKAKTAI DELDELPAWK PTSTTAATNS TSILNFEQHP NDCIIDNQMS NAQNSSFLPP  180
SLDSDSIADT IKSFFPMGGS STPHNSNSSA MQFHQSFSPT DFLSRSSNQT QDLRLSLQSF  240
KDPMLHHHHH HQQTEEGNSM FLDGSGWPER MVGWGGGASG GFPFSSPPTQ TTPFLQNDLF  300
NNNSQRGPLQ SSNTSSVRAW IDQPPFVGAA AGDHP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5zkt_A3e-2080133154Putative transcription factor PCF6
5zkt_B3e-2080133154Putative transcription factor PCF6
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor playing a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164) (PubMed:12931144, PubMed:17307931). Required during early steps of embryogenesis (PubMed:15634699). Participates in ovule develpment (PubMed:25378179). Activates LOX2 expression by binding to the 5'-GGACCA-3' motif found in its promoter (PubMed:18816164). {ECO:0000269|PubMed:12931144, ECO:0000269|PubMed:15634699, ECO:0000269|PubMed:17307931, ECO:0000269|PubMed:18816164, ECO:0000269|PubMed:25378179}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by the miRNA miR-JAW/miR319 (PubMed:12931144, PubMed:18816164). {ECO:0000269|PubMed:12931144, ECO:0000269|PubMed:18816164}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023768308.10.0transcription factor TCP4-like
SwissprotQ8LPR54e-76TCP4_ARATH; Transcription factor TCP4
TrEMBLA0A2J6L3X50.0A0A2J6L3X5_LACSA; Uncharacterized protein
STRINGPGSC0003DMT4000322691e-97(Solanum tuberosum)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G53230.11e-48TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 3
Publications ? help Back to Top
  1. Schommer C, et al.
    Control of jasmonate biosynthesis and senescence by miR319 targets.
    PLoS Biol., 2008. 6(9): p. e230
    [PMID:18816164]
  2. Ju Y, et al.
    Arabidopsis JINGUBANG Is a Negative Regulator of Pollen Germination That Prevents Pollination in Moist Environments.
    Plant Cell, 2016. 28(9): p. 2131-2146
    [PMID:27468890]
  3. Challa KR,Aggarwal P,Nath U
    Activation of YUCCA5 by the Transcription Factor TCP4 Integrates Developmental and Environmental Signals to Promote Hypocotyl Elongation in Arabidopsis.
    Plant Cell, 2016. 28(9): p. 2117-2130
    [PMID:27597774]
  4. Alvarez JP,Furumizu C,Efroni I,Eshed Y,Bowman JL
    Active suppression of a leaf meristem orchestrates determinate leaf growth.
    Elife, 2017.
    [PMID:27710768]
  5. Li J, et al.
    RABBIT EARS regulates the transcription of TCP4 during petal development in Arabidopsis.
    J. Exp. Bot., 2016. 67(22): p. 6473-6480
    [PMID:27838638]
  6. Sun X, et al.
    Activation of secondary cell wall biosynthesis by miR319-targeted TCP4 transcription factor.
    Plant Biotechnol. J., 2017. 15(10): p. 1284-1294
    [PMID:28233945]
  7. Kubota A, et al.
    TCP4-dependent induction of CONSTANS transcription requires GIGANTEA in photoperiodic flowering in Arabidopsis.
    PLoS Genet., 2017. 13(6): p. e1006856
    [PMID:28628608]
  8. Koyama T,Sato F,Ohme-Takagi M
    Roles of miR319 and TCP Transcription Factors in Leaf Development.
    Plant Physiol., 2017. 175(2): p. 874-885
    [PMID:28842549]
  9. Bresso EG,Chorostecki U,Rodriguez RE,Palatnik JF,Schommer C
    Spatial Control of Gene Expression by miR319-Regulated TCP Transcription Factors in Leaf Development.
    Plant Physiol., 2018. 176(2): p. 1694-1708
    [PMID:29133375]
  10. Vadde BVL,Challa KR,Nath U
    The TCP4 transcription factor regulates trichome cell differentiation by directly activating GLABROUS INFLORESCENCE STEMS in Arabidopsis thaliana.
    Plant J., 2018. 93(2): p. 259-269
    [PMID:29165850]
  11. Challa KR,Rath M,Nath U
    The CIN-TCP transcription factors promote commitment to differentiation in Arabidopsis leaf pavement cells via both auxin-dependent and independent pathways.
    PLoS Genet., 2019. 15(2): p. e1007988
    [PMID:30742619]