PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lj5g3v0816340.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Loteae; Lotus
Family E2F/DP
Protein Properties Length: 470aa    MW: 51362.4 Da    PI: 5.0671
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Lj5g3v0816340.1genomeKazusaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP841.2e-26149214171
          E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                      r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Lj5g3v0816340.1 149 RYDSSLGLLTRKFINLIKHAEDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 214
                      6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.4E-28147216IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.72E-17148212IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.6E-34149214IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.7E-24151214IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440749.68E-33227331No hitNo description
PfamPF164211.0E-33230329IPR032198E2F transcription factor, CC-MB domain
CDDcd146601.63E-47230331No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 470 aa     Download sequence    Send to blast
MSSTAGASDN RATPPLQPPN RPPLKRHLAF ASTKPPFAPP DDYHTFSAAA TTAAGPDSRR  60
GAHHEPEAVV VRSPFIKRKN GMNNNEGDSQ KWGNSPGGTN VMNSPFKTPV SAKGGRTHKL  120
KVSKEGRSCP PTPISNAGSP SPLTPANNRY DSSLGLLTRK FINLIKHAED GMLDLNKAAE  180
TLEVQKRRIY DITNVLEGIG LIEKKLKNRI HWKGIESSTP GAVDGDISML KAETEKLSSE  240
EQRLDDQIRE MQEKLRSLSE NENNQKCLFV TEEDIKAVPC FQNETLIAIK APHGTTLEVP  300
DPEEAVDYPQ RRYRIILRST MGPIDVYLIS QFEEKFEEIN GAEPPISLPL ASSSGSNEQL  360
VTETVPTEFS GIGLEPQAQL SSQGYSDLNA SQEFAGGMMK IVPSDADNDS DYWLLSDAEV  420
SITDMWKTDA SVDWNGVDML HPDFGLVSRP QTPSSGFAEA PPTAANSNQR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-24142215274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapLj5g3v0816340.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027366160.10.0transcription factor E2FA
SwissprotQ9FNY01e-165E2FA_ARATH; Transcription factor E2FA
TrEMBLV7BL690.0V7BL69_PHAVU; Uncharacterized protein
STRINGXP_007145806.10.0(Phaseolus vulgaris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-168E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]