PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID WALNUT_00006670-RA
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fagales; Juglandaceae; Juglans
Family E2F/DP
Protein Properties Length: 472aa    MW: 52555.5 Da    PI: 4.6619
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
WALNUT_00006670-RAgenomeJHUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.61e-23134193771
             E2F_TDP   7 rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                         +llt++f++ll+++e+gi++ln++a +L   +v  ++RRiYDi+NVLe++++iekk kn+i+wkg
  WALNUT_00006670-RA 134 GLLTKRFINLLKQAEDGILDLNKAAGAL---EV--QKRRIYDITNVLEGIGIIEKKLKNRIHWKG 193
                         68**************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.1E-24127195IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.4E-29128193IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.77E-14133194IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.1E-21134193IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.02E-42204310No hitNo description
SuperFamilySSF1440741.57E-30206310No hitNo description
PfamPF164213.7E-30209308IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 472 aa     Download sequence    Send to blast
MSGGARPPNC PEPPLTGSIQ FPTPPPKRNL AALASTKPPF LLPDDYYCFF SSVDSHRAAD  60
HEAEAIVVRS PQLKRNSGTD ENEVQSAEWA TGPGYTCVVN SILNTPVSIK EGRIYNRPKS  120
SKGNRVTKRE NFTGLLTKRF INLLKQAEDG ILDLNKAAGA LEVQKRRIYD ITNVLEGIGI  180
IEKKLKNRIH WKGLDASRPG VVEDDASELQ AELENLFMQE QSLDDQIRVM RERLRDLSED  240
ENNQKWLFVT KEDIKGIPCL QNETLLAIKA PHGTTLEAPD PDEAVDYTQR RYRIILRSTV  300
APIDVYLVSQ FEEKFEEMNG AEPPVSFPVA SCSVVNAEST LTLQAQPNHH MCYDINASQD  360
FVGGMMKIVP SDVDNDADYW LLSDAEVSIT DMWKTDGIPL RSTFSQFFPH VVLYLTLWML  420
NSLTPTMAAV ESTGMDVLHT DFGIADVCTP IPETPLSGIT EVPSMAVNST QR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-20127194674PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018851226.10.0PREDICTED: transcription factor E2FA-like isoform X1
SwissprotQ9FNY01e-130E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2I4H4Z00.0A0A2I4H4Z0_JUGRE; transcription factor E2FA-like isoform X1
STRINGVIT_08s0007g02510.t010.0(Vitis vinifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-134E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]