PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Jcr4S02423.30
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Jatropheae; Jatropha
Family E2F/DP
Protein Properties Length: 495aa    MW: 54737.4 Da    PI: 5.4148
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Jcr4S02423.30genomeKazusaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.12.6e-27144209171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                    r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Jcr4S02423.30 144 RYDSSLGLLTKKFVNLIKHAEDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 209
                    6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-29141211IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467859.93E-17144207IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.2E-34144209IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.5E-24146209IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440746.8E-33223326No hitNo description
CDDcd146602.94E-47223326No hitNo description
PfamPF164219.2E-33225324IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 495 aa     Download sequence    Send to blast
MSGSARASTR PPATAASSPP QGPILPPLRR HLAFATMKPP FVPPDDYHRF SSPSKNKAAD  60
REVEGIVVRS PPLKRKGSSG ENRGDSSEWA SSDVSNSPFQ TPVSAKGGRI YNRSKASKGN  120
RSGPQTPVSK IDSPSPLTPA GSCRYDSSLG LLTKKFVNLI KHAEDGMLDL NKAAETLEVQ  180
KRRIYDITNV LEGIGLIEKK LKNRIRWKGV DASRPGEPDG DASLLQAEIE KLSMEERGLD  240
DQIREMQERL KGFSEDEISQ KWLFVTEEDI KNIPCFQNET LIAIKAPHGT TLEVPDPDEA  300
VEYPQRRYRI ILRSTMGPID VYLVSQFEEN FEEMNGEPST SFPHASSSGS NEIPAREIIN  360
EQRMMKRFEP QVHQQVHSSF LDLDASQDLA GGMMKIVPSD VNNDADYWLL SDADVSITDM  420
WRTDTNVEWS EDMLSADFGI PDVHTPRAQT PPSGIAEVPS GGNSTQSGNW SSIWKKLTDG  480
KLGLSPIHLT RVAFI
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-24139210274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012074348.10.0transcription factor E2FA
SwissprotQ9FNY01e-168E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A067KIS90.0A0A067KIS9_JATCU; Uncharacterized protein
STRINGXP_002530154.10.0(Ricinus communis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-172E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]