PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Itr_sc001095.1_g00009.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Convolvulaceae; Ipomoeeae; Ipomoea
Family E2F/DP
Protein Properties Length: 382aa    MW: 43173.8 Da    PI: 9.3682
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Itr_sc001095.1_g00009.1genomeKazusaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP763.8e-241782171
                  E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                             rk+ksL+ll+++fl+l++++  +++ l+++ak+L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Itr_sc001095.1_g00009.1 17 RKQKSLGLLCSNFLSLYSREGVETIGLDDAAKQL---GV--ERRRIYDIVNVLESVGVLSRKAKNRYTWKG 82
                             79*****************999************...**..****************************98 PP

2E2F_TDP72.83.8e-23145225171
                  E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                              r+eksL+lltq+f+kl+ +++ ++++l+e+ak L+ +       ++k+RR+YDi+NVL++++ iek     ++k+++rw g
  Itr_sc001095.1_g00009.1 145 RREKSLGLLTQNFIKLFLCTNVDMLCLDEAAKILLGDgrppsINRTKVRRLYDIANVLSSMKFIEKthhpeTRKPAFRWLG 225
                              689**************************************97779*********************99999*******87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.109.0E-271584IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467856.12E-161780IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.7E-291782IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.7E-211882IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.3E-22141227IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.0E-32145225IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467857.48E-11147226IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.3E-17147225IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 382 aa     Download sequence    Send to blast
MALVSSASKD SGSVYCRKQK SLGLLCSNFL SLYSREGVET IGLDDAAKQL GVERRRIYDI  60
VNVLESVGVL SRKAKNRYTW KGFEAIPRAF QELKEEGLKE SFSAYSGDVS VQVSDDEEDD  120
RHSNPNVSSQ NEKSDSISAP KPDNRREKSL GLLTQNFIKL FLCTNVDMLC LDEAAKILLG  180
DGRPPSINRT KVRRLYDIAN VLSSMKFIEK THHPETRKPA FRWLGLKGKS ENQAANASED  240
NLGCNQSRKR VFGTELTNTT TKRCKLDKSK DAFGESMKSK LAAQVKCENL ENEFDRPKQD  300
LGSRTNRKSY QFGPFAPVTV PKFEASESGE RTKVIRELES LASTYHPQYH NQALRDLFSH  360
YMEAWKSWYL EIAGKKPIQM LS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-36172174228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_019197186.10.0PREDICTED: E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-117E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A0V0I5920.0A0A0V0I592_SOLCH; Putative E2F transcription factor-like E2FE-like
STRINGXP_009607525.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-119DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]