PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Itr_sc000784.1_g00004.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Convolvulaceae; Ipomoeeae; Ipomoea
Family E2F/DP
Protein Properties Length: 505aa    MW: 55196.2 Da    PI: 4.8607
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Itr_sc000784.1_g00004.1genomeKazusaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.61.9e-27182247171
                  E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                              r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Itr_sc000784.1_g00004.1 182 RYDSSLGLLTKKFINLIKHAEDGMIDLNNAADAL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 247
                              6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.2E-29181249IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.62E-17182245IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.3E-34182247IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.9E-24184247IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440748.89E-32261364No hitNo description
CDDcd146607.19E-46263364No hitNo description
PfamPF164215.3E-32263362IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 505 aa     Download sequence    Send to blast
MSGTPTRAAA PPPAPSNAPP ANGVSGAQIP RPTRRHLAFA SMKPPFVPPE DYHRFSTPGA  60
DVGLAAGNNH QPEAIIVKSP ALEGGTQTIT TYSFIMCRNV FYWCVQPMKR KGRAASCEAE  120
SSEWSASPGY TDMVNSPLQT PVSVKGGKAY GRSKTTKNNR SGPPTPVSNA ACPSPLTPVG  180
CRYDSSLGLL TKKFINLIKH AEDGMIDLNN AADALEVQKR RIYDITNVLE GIGLIEKKLK  240
NRIQWKGVDA SRPGDVDTDA TILRAEVENL SMEEQRLDGR IREMQEKLRG LSEDENDKRW  300
LFVTEEDIKT IPCFQNETLI AIKAPHGTTL EVPEPDEAVD YPQRRYRIIL RSTMGPIDVY  360
LVSQFEEKFE EMTGVEPSMS VPLASSSGSN DNPSTDRSTV TNNLPGNGSL AHDSQMSCDL  420
GASLEFNGGM MKIVPSDADN NTDYWLQSDP IPGLSLTEMW KTDGDIDWCM ENMLNEFGIS  480
EISTPRPQTP SAVADVPPAV NMPPR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-23175248274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_019176266.10.0PREDICTED: transcription factor E2FA-like
SwissprotQ9FNY01e-148E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A484LT200.0A0A484LT20_9ASTE; Uncharacterized protein
STRINGPGSC0003DMT4000423470.0(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-150E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]