PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Itr_sc000115.1_g00034.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Convolvulaceae; Ipomoeeae; Ipomoea
Family E2F/DP
Protein Properties Length: 319aa    MW: 35795.9 Da    PI: 8.4549
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Itr_sc000115.1_g00034.1genomeKazusaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP69.15.4e-221277171
                  E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                             rk+ksL+ll+++fl+l+ ++  +++ l+++a +L    v  +rRRiYDi+NVLe+++++++++kn + wkg
  Itr_sc000115.1_g00034.1 12 RKQKSLGLLCSNFLSLYDREGVETIGLDDAAMRL---GV--ERRRIYDIVNVLESVGVLARRAKNIYMWKG 77
                             79*****************999************...**..****************************98 PP

2E2F_TDP49.38.1e-161071672171
                  E2F_TDP  21 eegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                              + ++++l+++ak L+ +      +knk+RR+YDi+NVL++++ iek     ++k+++rw g
  Itr_sc000115.1_g00034.1 107 QMEMICLEDAAKILLGDgrppsMTKNKVRRLYDIANVLSSMKFIEKtqhpeTRKPAFRWLG 167
                              45899****************9999*********************9999999******87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.7E-251078IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.66E-161175IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.4E-251277IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.8E-191377IPR003316E2F/DP family, winged-helix DNA-binding domain
SMARTSM013721.8E-1396167IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.8E-12108167IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.104.3E-13108168IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.94E-8109168IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 319 aa     Download sequence    Send to blast
MASKDSGSVY SRKQKSLGLL CSNFLSLYDR EGVETIGLDD AAMRLGVERR RIYDIVNVLE  60
SVGVLARRAK NIYMWKGFAV VPNVLQELKE EGLKERIGAS DRSLSLQMEM ICLEDAAKIL  120
LGDGRPPSMT KNKVRRLYDI ANVLSSMKFI EKTQHPETRK PAFRWLGLEG KSADMSEINL  180
DCNQSKKRVF GTELTNTPIK RCKLVPLMDG DAAETKLQAQ IKCESLDCEA NRSNLDPGSR  240
TSAKGYQFGP FAPVSVPKDE AHESGHRSKL LSDCESLAST YRPQYHNQAL RELFHHYVEA  300
WSSWYSEVAA GKNPIEVQS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-141192388Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_019152589.11e-146PREDICTED: E2F transcription factor-like E2FE
SwissprotQ8LSZ48e-86E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A328DBC01e-142A0A328DBC0_9ASTE; Uncharacterized protein
STRINGXP_009607525.11e-133(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.23e-88DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]