PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Itr_sc000054.1_g00032.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Convolvulaceae; Ipomoeeae; Ipomoea
Family E2F/DP
Protein Properties Length: 442aa    MW: 48712.1 Da    PI: 4.4543
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Itr_sc000054.1_g00032.1genomeKazusaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP871.4e-27121186171
                  E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                              r+++sL+llt+kf++l+++se+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Itr_sc000054.1_g00032.1 121 RYDSSLGLLTKKFINLIKHSEDGILDLNNAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 186
                              6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.4E-29119188IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-34121186IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.04E-17121184IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.5E-24123186IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.36E-49196302No hitNo description
SuperFamilySSF1440741.12E-33198302No hitNo description
PfamPF164218.2E-34201300IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 442 aa     Download sequence    Send to blast
MQQQQAIKRQ QLPFTAAKPP FGDYHRFAAD PRMLPPQVPE GIVVKTPPLK RKKETAKYSL  60
VSGELNQGSG YSDANGPLQT PVSGKAQKAS RASKANRSAS QTAGNVGSPS SNNATPVGAC  120
RYDSSLGLLT KKFINLIKHS EDGILDLNNA ADTLEVQKRR IYDITNVLEG IGLIEKKLKN  180
RIQWKGLDVS STGEDESVAS LQAEVENLTM DERRIDEQIR EMQERLRDLS EDENNQRWLF  240
VTEEDIKNIP SFQDETLIAI KAPHGTTLEV PDPDEAVDYL QRRYRIVLRS TMGPIDVYLV  300
SQFEEKYEEI DAAAAPPNNP STSGADNNAT ATLEIEKSGV NEVGRQENET GTIPSDLGTS  360
EDFMGGIMKI VPDVDNGTDY WFMSDYAGIT AIWEDSHLAG LDWSDLITLD EDHTTTNVNT  420
PHAQTSPPTF AELPCATNTT IS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A8e-25121187774PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_019199609.10.0PREDICTED: transcription factor E2FB-like
SwissprotQ9FV711e-145E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A0V0II580.0A0A0V0II58_SOLCH; Putative transcription factor E2FB-like
STRINGSolyc11g068800.1.10.0(Solanum lycopersicum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-133E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]