PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Itr_sc000002.1_g00019.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Convolvulaceae; Ipomoeeae; Ipomoea
Family E2F/DP
Protein Properties Length: 370aa    MW: 41463.4 Da    PI: 9.2291
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Itr_sc000002.1_g00019.1genomeKazusaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.64.3e-232186171
                  E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                             rkeksL++l+++fl+l+ + + + + l+++a++L    v  +rRRiYDi+N+Le+++l+++++kn+++wkg
  Itr_sc000002.1_g00019.1 21 RKEKSLGVLCSNFLRLYDRDDVDCIGLDHAADQL---GV--ERRRIYDIVNILESVGLLSRRAKNQYTWKG 86
                             79****************9999************...**..****************************98 PP

2E2F_TDP74.41.2e-23142222171
                  E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                              rkeksL lltq+f+kl+ +s+ + ++l+++a++L+ +      +++k+RR+YDi+NV+ ++nliek     + k+++rw+g
  Itr_sc000002.1_g00019.1 142 RKEKSLALLTQNFIKLFLCSDVEFISLDNAASALLGNmhdptAMRTKVRRLYDIANVFASMNLIEKirhpeSGKPAFRWIG 222
                              79********************************999*********************************99*******98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.3E-251987IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467859.6E-162084IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.8E-282186IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.1E-202286IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.105.1E-22139222IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.6E-30142222IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.1E-18143222IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.18E-12144222IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 370 aa     Download sequence    Send to blast
MSSSSIHSDS QSKNPTSLYS RKEKSLGVLC SNFLRLYDRD DVDCIGLDHA ADQLGVERRR  60
IYDIVNILES VGLLSRRAKN QYTWKGFAAI PRTLDALKGE GLREKLSGQN IANVSRENEY  120
RPPSNSSTKQ DNTHELIKGD NRKEKSLALL TQNFIKLFLC SDVEFISLDN AASALLGNMH  180
DPTAMRTKVR RLYDIANVFA SMNLIEKIRH PESGKPAFRW IGQVGNPGNG SRSAANVTDL  240
KRTFGADITN TVPKRCKAGS SSDWKPSEHA TQYAKHGNLK DENSKVSPDR HKHGSKDFEF  300
GPFSPSSVPR EVLGNINVGQ IPNWENLAST YRPRYCNKAL SDLFGHYVEA WNSWYVAADA  360
DEKQHDQHLP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-36202123226Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_019185885.10.0PREDICTED: E2F transcription factor-like E2FF isoform X1
SwissprotQ8RWL01e-111E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLA0A328DSA60.0A0A328DSA6_9ASTE; Uncharacterized protein
STRINGXP_009771455.11e-144(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-112DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]