PlantTFDB
Plant Transcription Factor Database
v5.0
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MLOC_57269.4
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum
Family bHLH
Protein Properties Length: 188aa    MW: 20413.5 Da    PI: 6.0866
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MLOC_57269.4genomeIBSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH19.41.9e-0611521055
                  HHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
           HLH 10 rrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55
                  + RR+ri +++  L+el+P +    +k   Ka +L + ++Y++sLq
  MLOC_57269.4 11 QVRRERISERMRYLQELVPGC----DKVTGKAGMLDEIINYVQSLQ 52
                  67******************9....555*****************9 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088811.318151IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003534.4E-4757IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474598.9E-131168IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000836.63E-71356No hitNo description
Gene3DG3DSA:4.10.280.105.4E-131465IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 188 aa     Download sequence    Send to blast
MHSLILVRMV QVRRERISER MRYLQELVPG CDKVTGKAGM LDEIINYVQS LQKQVEFLSM  60
KIAAANPVVN FNIVDDLFGG RRMSQPCGPA AALPAMTLPM HHGQLDPSCL QMSNTAMQQM  120
QQPAAGFGLD MVLNHPYPLR SAAATPASAS AATSVESCLD VNGAAAWDIA SQNLFSGFDA  180
QFQSVQSE
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that binds DNA to G box 5'-CACGTG-3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light. {ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:24130508}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapMLOC_57269.4
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Accumulates strongly in response to blue light due to reduced preventing 26S proteasome-mediated degradation in an ADO1/ZTL and ADO2/LKP2 dependent manner, but levels decrease in the absence of blue light via 26S proteasome degradation (at protein level). {ECO:0000269|PubMed:24101505}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK3602380.0AK360238.1 Hordeum vulgare subsp. vulgare mRNA for predicted protein, complete cds, clone: NIASHv1113K05.
GenBankAK3606200.0AK360620.1 Hordeum vulgare subsp. vulgare mRNA for predicted protein, complete cds, clone: NIASHv1122A07.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020200434.14e-98transcription factor bHLH137-like
SwissprotQ8GY616e-30BH063_ARATH; Transcription factor bHLH63
TrEMBLA0A287UK381e-128A0A287UK38_HORVV; Uncharacterized protein
STRINGMLOC_57269.21e-126(Hordeum vulgare)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G34530.18e-32cryptochrome-interacting basic-helix-loop-helix 1
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Yang D,Zhao W,Meng Y,Li H,Liu B
    A CIB1-LIKE transcription factor GmCIL10 from soybean positively regulates plant flowering.
    Sci China Life Sci, 2015. 58(3): p. 261-9
    [PMID:25651969]
  3. Katsura Y, et al.
    An optogenetic system for interrogating the temporal dynamics of Akt.
    Sci Rep, 2015. 5: p. 14589
    [PMID:26423353]
  4. Taslimi A, et al.
    Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase.
    Nat. Chem. Biol., 2016. 12(6): p. 425-30
    [PMID:27065233]
  5. Liu Q, et al.
    The Blue Light-Dependent Polyubiquitination and Degradation of Arabidopsis Cryptochrome2 Requires Multiple E3 Ubiquitin Ligases.
    Plant Cell Physiol., 2016. 57(10): p. 2175-2186
    [PMID:27516416]
  6. Pathak GP, et al.
    Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2.
    Nucleic Acids Res., 2017. 45(20): p. e167
    [PMID:28431041]
  7. Duan L, et al.
    Understanding CRY2 interactions for optical control of intracellular signaling.
    Nat Commun, 2017. 8(1): p. 547
    [PMID:28916751]
  8. Quejada JR, et al.
    Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1.
    Nucleic Acids Res., 2017. 45(20): p. e172
    [PMID:29040770]
  9. Liu Y, et al.
    CIB1 and CO interact to mediate CRY2-dependent regulation of flowering.
    EMBO Rep., 2019.
    [PMID:30126927]