PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID HL.SW.v1.0.G002769.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus
Family E2F/DP
Protein Properties Length: 418aa    MW: 46145.6 Da    PI: 5.1471
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
HL.SW.v1.0.G002769.1genomeHOPBASEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.42.1e-27148213171
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                           r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  HL.SW.v1.0.G002769.1 148 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 213
                           6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.6E-29145215IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.2E-17148211IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-34148213IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.0E-24150213IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440745.49E-34226330No hitNo description
CDDcd146609.60E-48226330No hitNo description
PfamPF164213.6E-33229328IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 418 aa     Download sequence    Send to blast
MSGGGRAHNR PAPPPPLASG GAQIVPPLRR HLAFTSTKPP FVPPDDYHRF SSDGRRAADQ  60
EPEAIVVRSP LLKRKNALEN NEVDHRDWAS SPGYINIVNN SPMQTPVSAK GGRTYNRSKG  120
SKANRSTPQT PVSNAGSPSP LTPAGSCRYD SSLGLLTKKF INLIKHAEDG ILDLNKAAET  180
LEVQKRRIYD ITNVLEGIGL IEKKLKNRIR WKGLDASRPG EVDGDISLLQ AEVENLNMEE  240
RSLDDRIREM QERLRDLSED ENNQKWLFVT EEDIKGLPCF HNETLIAIKA PHGTTLEVPD  300
PDEAVDYTQR RYRIILRSTM GPIDVYLVSQ FEEKFEEMNS AEPPANFPIA SSSGSSEPTA  360
TEVITVESNT GKEIEPQPQH DHQVCPDINA LQEFPGGMMK IVPSDVDAWG GSSECNE*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-24143214274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015898822.10.0transcription factor E2FA isoform X2
RefseqXP_024922668.10.0transcription factor E2FA isoform X3
SwissprotQ9FNY01e-159E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2P5D9W80.0A0A2P5D9W8_PARAD; E2F Family
STRINGEMJ055330.0(Prunus persica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-164E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]