PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID mrna15311.1-v1.0-hybrid
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae; Fragaria
Family E2F/DP
Protein Properties Length: 778aa    MW: 85645.1 Da    PI: 6.6805
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
mrna15311.1-v1.0-hybridgenomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP855.7e-27385450171
                  E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                              r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  mrna15311.1-v1.0-hybrid 385 RYDSSLGLLTKKFITLIKQAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 450
                              6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.1E-28382452IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.31E-16385448IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.2E-34385450IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.3E-24387450IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440742.3E-31464567No hitNo description
CDDcd146603.39E-47466567No hitNo description
PfamPF164218.5E-31466565IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 778 aa     Download sequence    Send to blast
MAGLWRTMGT DDVAETRARS GSVVGDWIYP DLVAIPCTFV FPIGAPNPVT EGGDERSKAG  60
FYNQFGRLGF EGRFLTFWRL ADEIDSMAFG VQRRRRCGNL GGATMAVGLS VLHALWVGSE  120
LFRLRRFSDL FLVYNNSYLL LVEMGGLCPG NRTQRAMFVI IRRRVPCLVK WSQPPSGKMK  180
LGRSPSPSPL NPKPPPIPSA ALRFPQTLKI YPLLSPLVVF ANPRRSATVL AGRSTSMSGL  240
ARAPNRQPAP PPPPTGGGNG QIVPPMRRHL VFESNKPPFF PPADYHQFSG GGQRAADQEP  300
EAIVVRSPQF KRKGTSDNNE AENNDRTSSP GYNNISQSPF QTPVSTTKAG KTNNRTKASK  360
GKSGPQTPAS NAGSPCPLTP AGSCRYDSSL GLLTKKFITL IKQAEDGILD LNKAAETLEV  420
QKRRIYDITN VLEGIGLIEK KLKNRIRWKG FDASRPGDLD ADLAILQGEV ENLSLKERSL  480
DDRIREMEEK LRDLSGDENN RKWLFVTEED IKGLPCFQNE TLIAIKAPHG TTLEVPDPDE  540
AVDYPQRRYR IILRSTMGPI DVYLVSQFEE KFDDVNGAEP PVSFPIASVC GTDEQSTAEM  600
VAGHDRGKEI EPRVQQAQVD QTCSDVNASQ EFGGGMMKIV PSDVDNDADY WLLSGVDVSI  660
TDMWRTDSAI EWNGEDMLNA DFGLPDVSTP RPQTPPSGIV EVPSHAANYP QSFRIEYQES  720
HLDIDIDIPH PSGHDVELGH LNLLPLKNKN YRPGSQIACQ NLKILNYLVS ILILTLG*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-24380451274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapmrna15311.1-v1.0-hybrid
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004305631.10.0PREDICTED: transcription factor E2FA isoform X1
SwissprotQ9FNY01e-169E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2P6RCD70.0A0A2P6RCD7_ROSCH; Putative transcription factor E2F-DP family
STRINGXP_004305631.10.0(Fragaria vesca)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-174E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]