PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Thhalv10016580m
Common NameEUTSA_v10016580mg
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema
Family E2F/DP
Protein Properties Length: 487aa    MW: 52873.8 Da    PI: 4.6326
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Thhalv10016580mgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP81.76.3e-26167232171
          E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                      r+++sL+llt+kf++l++++++g ++ln++a++L   +v  ++RRiYDi+NVLe+++liek  kn+i wkg
  Thhalv10016580m 167 RYDSSLGLLTKKFVNLIKQAKDGLLDLNKAAETL---EV--QKRRIYDITNVLEGIDLIEKPLKNRILWKG 232
                      6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.2E-27163234IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.6E-32167232IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.58E-16167230IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.1E-22169232IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440745.49E-33245349No hitNo description
CDDcd146602.05E-49245349No hitNo description
PfamPF164211.9E-33248347IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 487 aa     Download sequence    Send to blast
MSGSVRSSPG PSQPPPPPPH HPPSSPSPAA SAPVVPPIRR HLAFASTKPP FHPSDDYHRF  60
TPYALTNNDR SLVNGCGVVD REEDAVVVRS PSRKRKSTMD VVTAPSNNGF TSSGFTSIPN  120
SPCQTPVSAK GGRVNTKSKA KGNKSIPQTP ISNADSPVTL TPSGSCRYDS SLGLLTKKFV  180
NLIKQAKDGL LDLNKAAETL EVQKRRIYDI TNVLEGIDLI EKPLKNRILW KGVDASRPGD  240
VDADVSVLQA EIENLSLEEQ ALDNQIREME ERLRDLSENE KNQKWLFVTE EDIKSLPGFQ  300
NQTLIAVKAP HGTTLEVPDP DEAADSPQRR YRIILRSTMG PIDVYLVSEF EGKFEDTNGS  360
VEPAASLPIA SCSGSTENHD IEALTVDNTG TDIEHQVSHD QAHAQPGDTS DLNYLQEQVG  420
GMLKITPSDV ENDDTDYWLL SNAEISMTDI WKTDSGIDWD YGIADVSTPP PVMGEIAPTA  480
VDTTPR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A5e-23162233274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
19196SRKRKS
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapThhalv10016580m
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF2425820.0AF242582.1 Arabidopsis thaliana E2F transcription factor-3 E2F3 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006410774.10.0transcription factor E2FA
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLV4MAR90.0V4MAR9_EUTSA; Uncharacterized protein
STRINGXP_006410774.10.0(Eutrema salsugineum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]