PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Thhalv10015650m
Common NameEUTSA_v10015650mg
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema
Family E2F/DP
Protein Properties Length: 386aa    MW: 42794.6 Da    PI: 4.6072
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Thhalv10015650mgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP871.4e-27129194171
          E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                      r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+i+wkg
  Thhalv10015650m 129 RYDSSLGLLTKKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIQWKG 194
                      6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.8E-29126196IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.9E-17129192IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.9E-35129194IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-24131194IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146602.26E-46205311No hitNo description
SuperFamilySSF1440741.05E-32207311No hitNo description
PfamPF164211.3E-32210309IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 386 aa     Download sequence    Send to blast
MSESHQDSQQ YPPSKRQHHP SLSSMKPPLV APGEYHRFDA AETRGGVAPD QVSEAIVLKS  60
ALKRKTDMVN QIDEPNELNT GVLQTPVSGK GGKAKKSSRS VKSNKTGTQA SGSNAGSPGN  120
NFAQAGTCRY DSSLGLLTKK FINLIKQAED GILDLNKAAD TLEVQKRRIY DITNVLEGIG  180
LIEKTLKNRI QWKGLDVSKP GETIESIANL QDEIQNLTAE EAKLDDQIRE SQERLTSLSE  240
DENNKRYLFV TEDDIKNLPC FQNKTLIAVK APHGTTLEVP DPDEAGGYPQ RRYRIILRST  300
MGPIDVYLVS QFEERFEEIP QADEPSNVPS TSGLPENQNV AMPMEEDSTD KNLETEEVDD  360
TQRVYSDIES HDFVDGIMKI VPPDLD
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-25129195774PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapThhalv10015650m
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF4000000.0AF400000.1 Thlaspi caerulescens E2F-related transcription factor 1 (E2F1) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006400728.20.0transcription factor E2FB isoform X1
SwissprotQ9FV710.0E2FB_ARATH; Transcription factor E2FB
TrEMBLV4N8X50.0V4N8X5_EUTSA; Uncharacterized protein (Fragment)
STRINGXP_006400728.10.0(Eutrema salsugineum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.30.0E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]