PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KZV48983.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Gesneriaceae; Didymocarpoideae; Trichosporeae; Loxocarpinae; Dorcoceras
Family E2F/DP
Protein Properties Length: 487aa    MW: 53192.3 Da    PI: 4.7218
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KZV48983.1genomeCNUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP83.31.9e-26161226171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                 r+++sL llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  KZV48983.1 161 RYDSSLSLLTKKFINLIKHAEDGELDLNKAADTL---QV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 226
                 6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.0E-28158228IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.8E-34161226IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467856.8E-17161224IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.5E-24163226IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.15E-46237343No hitNo description
SuperFamilySSF1440747.59E-33239343No hitNo description
PfamPF164211.5E-31242341IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 487 aa     Download sequence    Send to blast
MAGPGISTRD GAATPPSTAA ENGRIIPLQH TPPTAIRRHL PFASMKPPFA PPDDYHHFST  60
PARAAASDGS TADQLPDAIV VKSTPLKRKN VSGKNEAESN EWTASPGFND IANSPFRTPV  120
SGKGGRPNGR SKVTKNNRSI SSTPISNTDA PSPLTPASSC RYDSSLSLLT KKFINLIKHA  180
EDGELDLNKA ADTLQVQKRR IYDITNVLEG IGLIEKKLKN RIHWKGLDNS KPGEADEDAS  240
LLQAEIENLS MEERDLDERT RQMQEKLRRL SENVHNQKWL FVTEDDIKGL PCFQNETLIA  300
IKAPHGTTLE VPDPDEAVDY PQRRYRIILR STMGPIDVYL VSQFEEKFDE MNGVEQSTSI  360
PVASISGSNE NPAVQSCLPN NCQEIEASGQ ESQGFDSIFA TSQEFAGGMT KIVPSSVGDE  420
TDYWLLSDAD VSITDMWKTD SGIDWNAMDI LHEELNIAAT GATMQLAQPS SSSATADVLT  480
PVDLPPR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-24156227274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapKZV48983.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011094221.10.0transcription factor E2FA
SwissprotQ9FNY01e-154E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2Z7CQD60.0A0A2Z7CQD6_9LAMI; Uncharacterized protein
STRINGXP_009789426.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-159E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]