PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID DCAR_020719
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Apiales; Apiineae; Apiaceae; Apioideae; Scandiceae; Daucinae; Daucus
Family E2F/DP
Protein Properties Length: 455aa    MW: 49416.4 Da    PI: 4.9439
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
DCAR_020719genomeARS-USDAView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP855.8e-27150215171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  DCAR_020719 150 RYDSSLGLLTKKFINLIKQAEDGTLDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 215
                  6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.9E-28147217IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.9E-34150215IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.63E-17150213IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023197.1E-25152215IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146607.93E-28226314No hitNo description
SuperFamilySSF1440747.06E-17228314No hitNo description
PfamPF164211.2E-14265312IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 455 aa     Download sequence    Send to blast
MSRPQPSNGQ APPPSPSARP PVSNGGNGIP PPIKRHLQFA AMKPPFVPSD DYYRFGESRG  60
VADHEADVII VKSTPSKRKP GNYNEVESSR LSMSPAYTNT VKSPNQTPVS GKGGRVYGRS  120
NATKSLASVP QTPMSNAGSP SPLTPAGSCR YDSSLGLLTK KFINLIKQAE DGTLDLNNAA  180
ETLEVQKRRI YDITNVLEGI GLIEKKLKNR IHWKGIDASR PGEMEDDSNV LQAEVEKLSL  240
EEKRLDDRIR FNGFSLIKQS LIPELNKTLI AIKAPHGTTL EVPDPDEVVD YPQRRYRIIL  300
RSTMGPIDVY LVSQFEEKFD EMNSVQPSMS LPLASSTGSN DNPAAETAIV GHGLENGTMT  360
QDGHGVNSDL YTSEDISGGI MKILPSELDN DADYWLLTDP SISMTDMWKT DAGVEWDGAS  420
LLNEEFELPC ISPRPQTPPS GVADVSTAAN GTQR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-24145216274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAJ2515860.0AJ251586.1 Daucus carota mRNA for transcription factor E2F (E2F gene).
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017214842.10.0PREDICTED: transcription factor E2FA
SwissprotQ9FNY01e-135E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A164WKV20.0A0A164WKV2_DAUCS; Uncharacterized protein
STRINGVIT_08s0007g02510.t010.0(Vitis vinifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-140E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]