PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID DCAR_013863
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Apiales; Apiineae; Apiaceae; Apioideae; Scandiceae; Daucinae; Daucus
Family E2F/DP
Protein Properties Length: 393aa    MW: 44492.7 Da    PI: 6.9733
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
DCAR_013863genomeARS-USDAView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.14.7e-26137201170
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 
                  r+++sL+llt+kf++l++++++g+++ln+ a+ L   +v  ++RRiYDi+NVLe+++liek++kn+irwk
  DCAR_013863 137 RYDSSLGLLTKKFISLIHEAKDGTLDLNKTADVL---EV--RKRRIYDITNVLEGIGLIEKTAKNHIRWK 201
                  6899******************************...99..9***************************8 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-26134202IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.3E-32137202IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467857.75E-17137200IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023195.3E-24139201IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.18E-24216317No hitNo description
PfamPF164218.9E-23217315IPR032198E2F transcription factor, CC-MB domain
CDDcd146601.71E-32219318No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 393 aa     Download sequence    Send to blast
MASSAAGGGG GEELSRHLSA IHLHHQQHPH FYNTNTITQT HDIHIKKKPG RKRNYQNPFI  60
SPSPPAPTFQ PANIVGEDKG KSDETTTIHE YSNKHSAGVE HSPNLKVIRK PKVSIVKSEQ  120
ESYAENAENL NLATSCRYDS SLGLLTKKFI SLIHEAKDGT LDLNKTADVL EVRKRRIYDI  180
TNVLEGIGLI EKTAKNHIRW KDFDTKLRES EFHAAQLMAE IKSLYAEDNR VENLIRKTKE  240
QLRDLKFGQT SQKYLFVTEK DIMSLPHFKN QTVMVIKAPH ASYVEVPDPD EGNFARKEYR  300
LLVRSTTGPI NLFLLSKHDG EGEDDAVNDI KLSDASFRNG GRYQDENNFH SEESNMYKLD  360
KIVPSDSHID DDYWLRSDDS VCASDLWGTK HT*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-24133201372PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017246087.10.0PREDICTED: transcription factor E2FC-like isoform X1
SwissprotQ9FV704e-78E2FC_ARATH; Transcription factor E2FC
TrEMBLA0A165Y2Q20.0A0A165Y2Q2_DAUCS; Uncharacterized protein
STRINGVIT_18s0001g14110.t012e-98(Vitis vinifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA126252022
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.22e-80E2F/DP family protein
Publications ? help Back to Top
  1. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  2. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  3. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]