PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID DCAR_006178
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Apiales; Apiineae; Apiaceae; Apioideae; Scandiceae; Daucinae; Daucus
Family E2F/DP
Protein Properties Length: 425aa    MW: 47143.7 Da    PI: 4.64
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
DCAR_006178genomeARS-USDAView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.11.1e-26112177171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+ +liekk kn+i+wkg
  DCAR_006178 112 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGTGLIEKKLKNRIQWKG 177
                  6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.8E-28110179IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.43E-17112175IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.0E-34112177IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.6E-24114177IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.00E-45190294No hitNo description
SuperFamilySSF1440748.37E-32190294No hitNo description
PfamPF164212.1E-32193292IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 425 aa     Download sequence    Send to blast
MSAPNRNSLR PPLSDHRRFS SAATSSDAAV LQSPQMKRKF EGPEFEGDFN KQNPNSGFTE  60
DVSSPFQRPA PKKGGKPQKV PRIAKFNQTA STPVSGVGSP SANNPTPAGP CRYDSSLGLL  120
TKKFINLIKH AEDGILDLNK AADTLEVQKR RIYDITNVLE GTGLIEKKLK NRIQWKGIDA  180
AMPRDIEETV GSLQADVEHL SMEEHSLDEK IREAQDKLRD LSEDKNNQRW LFVTEEDIKL  240
LPCFQNETLI AIKAPHGTTL EVPDPDEAVD YPQRRYRIVL RSTMGPIDVY LVSQFEEKLE  300
EFKSAEAPQS LAPVTAEESR GTETEMQVKE DNAKCSDSIT SQDFVNGIMK IVPDVDIDAD  360
YWLISEGDIS ITDMWSTGLN SMTSTTAGIE WNEIGQLYDD YTVANFSRPL SSAEAPSSVK  420
STEK*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A9e-27107178274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_017231895.10.0PREDICTED: transcription factor E2FB-like isoform X1
SwissprotQ9FV711e-130E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A166DJZ40.0A0A166DJZ4_DAUCS; Uncharacterized protein
STRINGVIT_06s0080g01110.t011e-179(Vitis vinifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-133E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]