PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cucsa.185850.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family E2F/DP
Protein Properties Length: 463aa    MW: 51292.1 Da    PI: 4.5299
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cucsa.185850.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP871.4e-27140205171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Cucsa.185850.1 140 RYDSSLGLLTKKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 205
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.6E-29138207IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.94E-17140203IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.0E-35140205IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.0E-24142205IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146606.03E-48216322No hitNo description
SuperFamilySSF1440742.51E-34217322No hitNo description
PfamPF164218.5E-34221320IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 463 aa     Download sequence    Send to blast
MSGSRPPNSS GHLPDQIMHS LKRQLPFSSM KPPFASSGDY HRFTPDSRLA DQEPDAILVK  60
SPQLKRKSEV ADYEAESTDR AIGPRFAEVV NSPHQTPASV KGGKGSKSRL TKCSRSGPQT  120
PMSNVGSPST NNLTPAGPCR YDSSLGLLTK KFINLIKQAE DGILDLNKAA DTLEVQKRRI  180
YDITNVLEGI GLIEKKLKNR IQWKGLDVSR SGDVDDNYAD LQAEVENLTM EERGLDEQIR  240
EMQERLRDLS EDENNQRWLF VTEEDIKGLP CFQNETLIAI KAPHGTTLEV PDPDEAVDYP  300
QRRYRIVLRS TMGPIDVYLV SQFEAKFEEI NAAEVPPSLP SSSGLNEAPT TTLVTEDTRG  360
KEIETREQDV HRMCSDLNAS QDFVGGIMKI VPSVVDSDAD YWLLSDADVS ITDMWRTEPS  420
VEWNELGTFH EDYSIGTVSS PQTQTPLPND APDLPSTNPS SS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-27135206274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818421e-109LN681842.1 Cucumis melo genomic scaffold, anchoredscaffold00022.
GenBankLN7132591e-109LN713259.1 Cucumis melo genomic chromosome, chr_5.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004140164.10.0PREDICTED: LOW QUALITY PROTEIN: transcription factor E2FB
SwissprotQ9FV711e-155E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A1S3BLR60.0A0A1S3BLR6_CUCME; transcription factor E2FB isoform X2
STRINGXP_004140164.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-158E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]