PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cucsa.083720.1
Common NameCsa_6G454430
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family E2F/DP
Protein Properties Length: 479aa    MW: 53380.8 Da    PI: 5.4638
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cucsa.083720.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP811e-25151216171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++++gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn i wkg
  Cucsa.083720.1 151 RYDSSLGLLTKKFINLIKQARDGILDLNKAAETL---QV--QKRRIYDITNVLEGIGLIEKKLKNIIYWKG 216
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.7E-28148218IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.43E-17151214IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.1E-31151216IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.7E-23153216IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.45E-32230333No hitNo description
PfamPF164212.2E-31232331IPR032198E2F transcription factor, CC-MB domain
CDDcd146601.99E-44232333No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 479 aa     Download sequence    Send to blast
MRGASRAPKP SEPLPLPHSH TAQILPPLNR HLAFDSHNPP FVPPGHYYHF AGDASSNAID  60
KPDTIVVKPL LSSAKSKQKG VMYNNMVKSN DYIHDEGSSK DALSCVQTPV SAKGGRVNNR  120
SKTSRKTTSG PQTPISDTST YSPLTPAGNC RYDSSLGLLT KKFINLIKQA RDGILDLNKA  180
AETLQVQKRR IYDITNVLEG IGLIEKKLKN IIYWKGFNQQ IPGNVDSDAS MLQVDVENLS  240
FEERRLDDKI RAMQERLRNL SEDDNIQKWL FVTEDDIKNL PCFQNETLIA IKAPHGTTLE  300
VPDPDEAVDY PQRRYRIVLR STMGPIDVYL VSQFEEKFEE MNVVQPPSSF LHASSSGSNE  360
HLATEAIIGE SSRNEMEPQA HLSQHSSSCD VNGSNEFPGG MMKILPSEVD NDADYWLLSD  420
AEVSITDMWR TDSDIAWDQS DMVPHDFLLS DVNTQRPRLG SPHSETAEAP SDVNLRQR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-23143216273PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818761e-115LN681876.1 Cucumis melo genomic scaffold, anchoredscaffold00068.
GenBankLN7132621e-115LN713262.1 Cucumis melo genomic chromosome, chr_8.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011657728.10.0PREDICTED: transcription factor E2FA-like isoform X4
SwissprotQ9FNY01e-148E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A0A0KF090.0A0A0A0KF09_CUCSA; Uncharacterized protein
STRINGXP_004143395.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-153E2F transcription factor 3
Publications ? help Back to Top
  1. Ren Y, et al.
    An integrated genetic and cytogenetic map of the cucumber genome.
    PLoS ONE, 2009. 4(6): p. e5795
    [PMID:19495411]
  2. Guo S, et al.
    Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types.
    BMC Genomics, 2010. 11: p. 384
    [PMID:20565788]
  3. Li Z, et al.
    RNA-Seq improves annotation of protein-coding genes in the cucumber genome.
    BMC Genomics, 2011. 12: p. 540
    [PMID:22047402]
  4. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]