PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PK18387.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Cannabis
Family E2F/DP
Protein Properties Length: 474aa    MW: 52460.7 Da    PI: 4.8797
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PK18387.1genomeCCBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.91.5e-27148213171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                r+++sL+llt+kf++l++++e+gi++ln++a++L   dv  ++RRiYDi+NVLe+++liekk kn+irwkg
  PK18387.1 148 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---DV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 213
                6899******************************...**..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.5E-29145215IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-34148213IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.13E-17148211IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.1E-24150213IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.39E-47226330No hitNo description
SuperFamilySSF1440741.44E-33226330No hitNo description
PfamPF164211.2E-32229328IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 474 aa     Download sequence    Send to blast
MSGGGRAHNR PAHPPPLASG GAQIVPPLRR HLAFTSTKPP FVPPDDYHRF SSDGRRAADQ  60
EPEAIVVRSP LLKRKNALQN NEVDHRDWAS SPGYINIVNN SPMQTPVSAK GGRTYNRSKG  120
AKANRSAPQT PVSNTGSPSP LTPAGSCRYD SSLGLLTKKF INLIKHAEDG ILDLNKAAET  180
LDVQKRRIYD ITNVLEGIGL IEKKLKNRIR WKGLDASRPG DVDGDISLLQ AEVENLNMEE  240
RGLDDRIREM QERLRDLSED ENNQKWLFVT EEDIKGLPCF HNETLIAIKA PHGTTLEVPD  300
PDEAVDYAQR RYRIILRSTM GPIDVYLVSQ FEEKFEDMNS AEPPASFPIA SSSGSSEPTV  360
TEVITVGSST VKEIEPQAQH DHQVCPDTNP LQEFPGGMMK IVPSDVDNDA DYWLLSDAEV  420
SITDMWKTDS VVDWDGPDIL HPDFVMPDVS TPRPETPPSG ITNVPNTSVD FPQR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-24143214274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00661PBMTransfer from Pp3c1_6880Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024026841.10.0transcription factor E2FA, partial
SwissprotQ9FNY01e-176E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2P5D9W80.0A0A2P5D9W8_PARAD; E2F Family
STRINGEMJ055330.0(Prunus persica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-170E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]