PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Carubv10016005m
Common NameCARUB_v10016005mg
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella
Family bZIP
Protein Properties Length: 679aa    MW: 74043.2 Da    PI: 6.8041
Description bZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Carubv10016005mgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1bZIP_131.34.6e-10192239350
                      XXCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
           bZIP_1   3 elkrerrkqkNReAArrsRqRKkaeieeLeekvkeLeaeNkaLkkele 50 
                      ++k+  r ++NRe+A+ sR+RKk+++eeLe+kvk++ a   +L  ++ 
  Carubv10016005m 192 DDKKRLRQIRNRESAQLSRLRKKQQTEELERKVKSMNATIAELNGKIA 239
                      79*********************************9998877776665 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.20.5.1701.1E-12186252No hitNo description
SMARTSM003381.3E-11190254IPR004827Basic-leucine zipper domain
PROSITE profilePS5021710.048192255IPR004827Basic-leucine zipper domain
PfamPF001709.3E-9193251IPR004827Basic-leucine zipper domain
SuperFamilySSF579594.13E-10194252No hitNo description
CDDcd147041.70E-15195245No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006990Biological Processpositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0009408Biological Processresponse to heat
GO:0005635Cellular Componentnuclear envelope
GO:0005654Cellular Componentnucleoplasm
GO:0005783Cellular Componentendoplasmic reticulum
GO:0016021Cellular Componentintegral component of membrane
GO:0048471Cellular Componentperinuclear region of cytoplasm
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 679 aa     Download sequence    Send to blast
MVTTQSTSVI VPPPETPNLN PSMLSDSDII SFPPLDPLFL SDSDPISMDA PLSDLDFLLD  60
DENGDFADFD FPFDSSDDFF DFDLAEPAAA VIPEEMGNNR SNLDSSENRD GDGGAEGRSD  120
SVHSQVSSQG SKTTFVSDTV DALSSPESSN HKKSSVSKRK KEKEDSGLEH RSRKYQKSDD  180
KSVATNNEED DDDKKRLRQI RNRESAQLSR LRKKQQTEEL ERKVKSMNAT IAELNGKIAY  240
VMAENVALRQ QMAVASGAPP MNPYMAAPPL PYQWMPYPPY PVRGYGSQTP LVPIPKLTPK  300
PVSSCRSKKT ESKKNEGKSK LKKVASISFI GILFFVFLFG TLVPFMNVNY GGESGSFGGL  360
SKYDGHRYYH EHKGKVLMVG DGSDVRRESG ISDGHLHSSR RVHGDSDSCG GVDYNPHPKI  420
EGRPSSVSNA SDPLFASLYV PRNNGLVKID GNLIIHSVLA SEKATALAKK NITATVKTKE  480
PDLTIPGALS SALAVPELRG NAAMLPQSMA LSSEGKRLHQ WFHEGGSGTL MDYSMCTEVF  540
QFDIAPGAIV PSSVSNISAE QLQNVTTHGK RMKNRRILEG LPVSRLASEL NITGTQPNKE  600
TQNKTFNGNT KNKPNSSSSM VVSVLLDPRE IVDSETDRVV PPNPKSLSRI FVVVLLDSVK  660
YVTYSCVLPR SGLHLVAT*
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator involved in ER stress responses. Functions as a stress sensor and transducer in ER stress signaling pathway. After proteolysis by SBT6.1 (S1P) and S2P, the N-terminal bZIP component is translocated to the nucleus, where it activates the expression and production of ER chaperones (PubMed:18156219, PubMed:18634751, PubMed:18849477, PubMed:20876872). Following ER stress, activates proteins involved in brassinosteroid (BR) signaling, which is required for stress acclimation and growth (PubMed:20876872). {ECO:0000269|PubMed:18156219, ECO:0000269|PubMed:18634751, ECO:0000269|PubMed:18849477, ECO:0000269|PubMed:20876872}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00345DAPTransfer from AT3G10800Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapCarubv10016005m
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By heat shock. {ECO:0000269|PubMed:18849477}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK2269280.0AK226928.1 Arabidopsis thaliana mRNA for bZIP transcription factor AtbZip28, complete cds, clone: RAFL09-25-P21.
GenBankBT0025020.0BT002502.1 Arabidopsis thaliana putative bZIP transcription factor (At3g10800) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006296784.10.0bZIP transcription factor 28
SwissprotQ9SG860.0BZP28_ARATH; bZIP transcription factor 28
TrEMBLR0G2L90.0R0G2L9_9BRAS; Uncharacterized protein
STRINGXP_006296784.10.0(Capsella rubella)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM143971822
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G10800.10.0bZIP family protein
Publications ? help Back to Top
  1. Deng Y,Srivastava R,Howell SH
    Protein kinase and ribonuclease domains of IRE1 confer stress tolerance, vegetative growth, and reproductive development in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2013. 110(48): p. 19633-8
    [PMID:24145452]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Nagashima Y,Iwata Y,Ashida M,Mishiba K,Koizumi N
    Exogenous salicylic acid activates two signaling arms of the unfolded protein response in Arabidopsis.
    Plant Cell Physiol., 2014. 55(10): p. 1772-8
    [PMID:25138441]
  4. Sun L,Zhang SS,Lu SJ,Liu JX
    Site-1 protease cleavage site is important for the ER stress-induced activation of membrane-associated transcription factor bZIP28 in Arabidopsis.
    Sci China Life Sci, 2015. 58(3): p. 270-5
    [PMID:25634523]
  5. Zhang L,Chen H,Brandizzi F,Verchot J,Wang A
    The UPR branch IRE1-bZIP60 in plants plays an essential role in viral infection and is complementary to the only UPR pathway in yeast.
    PLoS Genet., 2015. 11(4): p. e1005164
    [PMID:25875739]
  6. Ma ZX, et al.
    The THERMOSENSITIVE MALE STERILE 1 Interacts with the BiPs via DnaJ Domain and Stimulates Their ATPase Enzyme Activities in Arabidopsis.
    PLoS ONE, 2015. 10(7): p. e0132500
    [PMID:26186593]
  7. Sagor GH, et al.
    The polyamine spermine induces the unfolded protein response via the MAPK cascade in Arabidopsis.
    Front Plant Sci, 2015. 6: p. 687
    [PMID:26442007]
  8. Kørner CJ,Du X,Vollmer ME,Pajerowska-Mukhtar KM
    Endoplasmic Reticulum Stress Signaling in Plant Immunity--At the Crossroad of Life and Death.
    Int J Mol Sci, 2015. 16(11): p. 26582-98
    [PMID:26556351]
  9. Zeng Y, et al.
    Unique COPII component AtSar1a/AtSec23a pair is required for the distinct function of protein ER export in Arabidopsis thaliana.
    Proc. Natl. Acad. Sci. U.S.A., 2015. 112(46): p. 14360-5
    [PMID:26578783]
  10. Meng Z,Ruberti C,Gong Z,Brandizzi F
    CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses.
    Plant J., 2017. 89(3): p. 486-501
    [PMID:27747970]
  11. Nawkar GM, et al.
    HY5, a positive regulator of light signaling, negatively controls the unfolded protein response in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2017. 114(8): p. 2084-2089
    [PMID:28167764]
  12. Iwata Y, et al.
    Activation of the Arabidopsis membrane-bound transcription factor bZIP28 is mediated by site-2 protease, but not site-1 protease.
    Plant J., 2017. 91(3): p. 408-415
    [PMID:28407373]
  13. Zhang SS, et al.
    Tissue-Specific Transcriptomics Reveals an Important Role of the Unfolded Protein Response in Maintaining Fertility upon Heat Stress in Arabidopsis.
    Plant Cell, 2017. 29(5): p. 1007-1023
    [PMID:28442596]
  14. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  15. Kataoka R,Takahashi M,Suzuki N
    Coordination between bZIP28 and HSFA2 in the regulation of heat response signals in Arabidopsis.
    Plant Signal Behav, 2017. 12(11): p. e1376159
    [PMID:28873003]
  16. Ruberti C,Lai Y,Brandizzi F
    Recovery from temporary endoplasmic reticulum stress in plants relies on the tissue-specific and largely independent roles of bZIP28 and bZIP60, as well as an antagonizing function of BAX-Inhibitor 1 upon the pro-adaptive signaling mediated by bZIP28.
    Plant J., 2018. 93(1): p. 155-165
    [PMID:29124827]
  17. Kim JS,Yamaguchi-Shinozaki K,Shinozaki K
    ER-Anchored Transcription Factors bZIP17 and bZIP28 Regulate Root Elongation.
    Plant Physiol., 2018. 176(3): p. 2221-2230
    [PMID:29367234]