PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID cra_locus_9387_iso_2
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus
Family E2F/DP
Protein Properties Length: 513aa    MW: 57314.4 Da    PI: 4.8434
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
cra_locus_9387_iso_2genomeMPGR-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.32.2e-27129194171
                              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                                          r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  cra_locus_9387_iso_2_len_2072_ver_3 129 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 194
                                          6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.8E-29127196IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.45E-17129192IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.2E-35129194IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.8E-24131194IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.74E-42205347No hitNo description
SuperFamilySSF1440742.62E-31207284No hitNo description
PfamPF164213.7E-32210345IPR032198E2F transcription factor, CC-MB domain
SuperFamilySSF1440742.62E-31328347No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 513 aa     Download sequence    Send to blast
MQQQQQQQAL KRQLPFTSMK RPFGDYHHFS TDPHRSRDPE AVVVKSPPPL PLKRKSQATD  60
AEAESTEQNL GLGHSGNVNN SLKTPVSGKS GKVQKAPRVT KTSRAASQTP ATNVGSPSGN  120
HLTPVGPCRY DSSLGLLTKK FINLIKHAED GILDLNKAAD TLEVQKRRIY DITNVLEGIG  180
LIEKKLKNRI QWKGLDVSRP GEVDESVASL QADIENLSME EGRLDEQIRE MQETLRELSE  240
DENNQKWLFV TEEDIKSLPC FQNETLIAIK APHGTTLEVP DPDEVFLFQS LDYPYLIXEL  300
RNSKWLVRAP SEAMSLLFHQ AVDYPQRRYR IVLRSTMGPI DVYLVSQFEE KFEEINAIEA  360
PPSIPSTLGV NENVASTSGA KEGVGNEIEQ KAQEDNRICS DIGTSQDFVS GIMKIVPDVD  420
SDADYWLLSD ADVSITXHVE DGIGVDWNEL DTIPETYTMA NVSTPVAHSP PQPEEMPSTS  480
NHPGSXARIS ERLKQDAWAR YLRKLEEDAS KHQ
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-26124195274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027083093.10.0transcription factor E2FB-like
SwissprotQ9FV711e-141E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A068UEG00.0A0A068UEG0_COFCA; Uncharacterized protein
STRINGXP_006424133.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA10772484
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]