PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID cra_locus_4762_iso_2
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus
Family C2H2
Protein Properties Length: 370aa    MW: 42640.3 Da    PI: 6.6252
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
cra_locus_4762_iso_2genomeMPGR-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H212.30.000578100323
                                          ET..TTTEEESSHHHHHHHHHHT CS
                              zf-C2H2   3 Cp..dCgksFsrksnLkrHirtH 23 
                                          C+   Cgk+F +   L++H   H
  cra_locus_4762_iso_2_len_1668_ver_3  78 CSyeGCGKTFIDAGALRKHSHIH 100
                                          77779**************7766 PP

2zf-C2H2157e-05105129123
                                          EEET..TTTEEESSHHHHHHHHHHT CS
                              zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                                          y C+  +Cgk F ++s LkrH   H
  cra_locus_4762_iso_2_len_1668_ver_3 105 YICHyeNCGKKFLDSSKLKRHFLIH 129
                                          89*******************8877 PP

3zf-C2H221.75.3e-07135159123
                                          EEET..TTTEEESSHHHHHHHHHHT CS
                              zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                                          ++Cp   Cgk Fs   nL++H++tH
  cra_locus_4762_iso_2_len_1668_ver_3 135 FVCPheGCGKAFSLDFNLRSHMKTH 159
                                          89**********************9 PP

4zf-C2H217.61e-05165189123
                                          EEET..TTTEEESSHHHHHHHHHHT CS
                              zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                                          + Cp  dCgk++ + + Lk+Hi++H
  cra_locus_4762_iso_2_len_1668_ver_3 165 HICPyaDCGKRYAHEYKLKNHISSH 189
                                          68**********************6 PP

5zf-C2H216.13.3e-05227252123
                                          EEET..TTTEEESSHHHHHHHHHH.T CS
                              zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                                          y+Cp   C+k + + + L+ H+r+ H
  cra_locus_4762_iso_2_len_1668_ver_3 227 YTCPyeGCDKAYIHEYKLNLHLRReH 252
                                          9**********************999 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.160.609.1E-1471102IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.78376105IPR007087Zinc finger, C2H2
SMARTSM003550.003276100IPR015880Zinc finger, C2H2-like
PROSITE patternPS00028078100IPR007087Zinc finger, C2H2
SuperFamilySSF576674.59E-879129No hitNo description
Gene3DG3DSA:3.30.160.607.9E-14103125IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.013105129IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015714.066105134IPR007087Zinc finger, C2H2
PROSITE patternPS000280107129IPR007087Zinc finger, C2H2
SuperFamilySSF576671.39E-14116169No hitNo description
Gene3DG3DSA:3.30.160.603.5E-20126159IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003553.1E-4135159IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015712.695135164IPR007087Zinc finger, C2H2
PROSITE patternPS000280137159IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.602.9E-8160191IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS501579.245165194IPR007087Zinc finger, C2H2
SMARTSM003550.0069165189IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280167190IPR007087Zinc finger, C2H2
SuperFamilySSF576679.66E-6221250No hitNo description
Gene3DG3DSA:3.30.160.609.5E-9221250IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.097227257IPR007087Zinc finger, C2H2
SMARTSM003550.0019227252IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280229252IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 370 aa     Download sequence    Send to blast
METHMNHNLF ERRSITKSRA PAVKWFKEWV PQDVVATGGK CQLLRWVNEA TLKALREKKE  60
PELPEPEPEP TTEVLFLCSY EGCGKTFIDA GALRKHSHIH GERQYICHYE NCGKKFLDSS  120
KLKRHFLIHT GERDFVCPHE GCGKAFSLDF NLRSHMKTHS QENYHICPYA DCGKRYAHEY  180
KLKNHISSHH EKNVVEPTKY VPPAEKPVKT PKSSNATYAS ASSDRPYTCP YEGCDKAYIH  240
EYKLNLHLRR EHPGHSKEEN AKNVQFTADN DMDEASDHDP YPAKRSNDKK PSRSKPNLKL  300
PPAKVAQRKG STASQANMSV MKKQWPVKEE VYDEEDSEET EEERDNVGDG WRYAGNGDDD  360
DDDEETEYED
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ubd_C4e-35782484117PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtDual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269|PubMed:22508367, ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269|PubMed:26961720}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_022897013.10.0zinc finger transcription factor YY1
SwissprotQ2V3L31e-147YY1_ARATH; Zinc finger transcription factor YY1
TrEMBLA0A068TML90.0A0A068TML9_COFCA; Uncharacterized protein
STRINGPGSC0003DMT4000234590.0(Solanum tuberosum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA73432332
Publications ? help Back to Top
  1. Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H
    The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4.
    DNA Res., 2001. 8(6): p. 285-90
    [PMID:11853315]
  2. Li T,Wu XY,Li H,Song JH,Liu JY
    A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
    Mol Plant, 2016. 9(5): p. 650-661
    [PMID:26961720]
  3. Wu XY,Li T
    A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.
    Front Plant Sci, 2017. 8: p. 323
    [PMID:28348572]