PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID cra_locus_10725_iso_2
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthinae; Catharanthus
Family C2H2
Protein Properties Length: 492aa    MW: 53190.7 Da    PI: 6.7271
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
cra_locus_10725_iso_2genomeMPGR-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H213.80.00017121146123
                                           EEET..TTTEEESSHHHHHHHHHH.T CS
                               zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                                           ++C   +C ksF  ks++++Hi+  H
  cra_locus_10725_iso_2_len_2129_ver_3 121 FVCAapHCLKSFLKKSDFVSHINEnH 146
                                           899999****************9988 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd001620.0092370104No hitNo description
PROSITE patternPS0051808695IPR017907Zinc finger, RING-type, conserved site
PROSITE profilePS501579.827121151IPR007087Zinc finger, C2H2
PROSITE patternPS000280123146IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 492 aa     Download sequence    Send to blast
MLQIRLSKPS SEGGATKPLP ADSVTVACPD HLILADLPVA KSLGSPTANA LVKIIGRRSR  60
RQLGERVHFC VHCDLPIAIY GRLSPCEHVF CLDCARSDSL CFLCDERIQK IQTIKMMEGL  120
FVCAAPHCLK SFLKKSDFVS HINENHADLL PPSAEKDGND SEAISARKPA ASDSTVQAPP  180
RPSFSGSNSQ VHDREAYRMQ SRDQPPTRPV MQPKGMPAFP GPIQNHLLEQ QADNNAPPGF  240
DRFGPQNRFA QQTFDSPSGM RQELGQVQDK QQGLVPESPF REYPMQPNQP PNFAVPINPN  300
PAPAQFGYPH FVPDGSQPFY GAYEMARPES TPEVGPEQGS LLGFPPGPAG GMNFGESYPR  360
PWNMGPAVGS FDPSAGPGTV DGFMSASDPQ GRPASFQGDY GRNQGILPSN LPPSSANKGM  420
DSAQGGNSMD PRDGKGILAP QPVSLPPPPP PFAVHLPQAK RGKFYSNEMN NDGQSFGWQN  480
EKRDSFGSSS RD
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2mq1_A2e-1667146185E3 ubiquitin-protein ligase Hakai
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtProbable E3 ubiquitin-protein ligase which is a subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs (PubMed:28503769). Associates with MTA, MTB, FIP37 and VIR to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences (PubMed:28503769). N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:28503769). {ECO:0000269|PubMed:28503769}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027068481.10.0E3 ubiquitin-protein ligase Hakai-like
SwissprotQ9LFC03e-97HAKAI_ARATH; E3 ubiquitin-protein ligase HAKAI homolog
TrEMBLA0A068UD820.0A0A068UD82_COFCA; Uncharacterized protein
STRINGXP_009786415.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA640445
Publications ? help Back to Top
  1. Růžička K, et al.
    Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI.
    New Phytol., 2017. 215(1): p. 157-172
    [PMID:28503769]