PlantRegMap
Plant Transcription Factor Database
PlantTFDB
v5.0
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID evm.model.supercontig_195.40
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Caricaceae; Carica
Family E2F/DP
Protein Properties Length: 437aa    MW: 48085.6 Da    PI: 4.6338
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
evm.model.supercontig_195.40genomeASGPBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.44.4e-27152216170
                       E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 
                                   r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wk
  evm.model.supercontig_195.40 152 RYDSSLGLLTKKFINLIQQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWK 216
                                   6899******************************...99..****************************7 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.7E-28150216IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.36E-17152215IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.3E-34152217IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.6E-24154216IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440741.83E-20205287No hitNo description
CDDcd146609.48E-34206287No hitNo description
PfamPF164212.2E-22212285IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 437 aa     Download sequence    Send to blast
MSGSQAPNQH TMQPQTQTQS QSQSQSQSQP PLKRQLPFSS MKPPFSVPAD YHRFSSAGTR  60
RATDQEPEAV VVKSPPLKRK SDAVNREAES SEWTGPGYTE VVNSSLQTPA SGKGGKAEKT  120
SRLTKSNKSG SQTPVSNLGS PGNNLTPAGP CRYDSSLGLL TKKFINLIQQ AEDGILDLNK  180
AADTLEVQKR RIYDITNVLE GIGLIEKKLK NRIQWKYGML IQWLFVTEED IKSLPCFQNE  240
TLIAIKAPHG TTLEVPDPDE AVDYPQRRYR IVLRSTMGPI DVYLVSQFEE KFEEIHGVEA  300
PPDVPSSSGF HENTATAIMT DDSREKLEME GQDMHQTFSD VNSSQDFVSG IMKIVPSEID  360
SDSDYWLLSD AGVSITDMWR TEPGVEWNDF DVLGEDYAIT NMNANVTQPQ TPPLPPPPQN  420
PPNPGEMPST ANSTGT*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-27147216272PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapevm.model.supercontig_195.40
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021887509.10.0transcription factor E2FB
SwissprotQ9FV711e-140E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A067KKC20.0A0A067KKC2_JATCU; Uncharacterized protein
STRINGevm.model.supercontig_195.400.0(Carica papaya)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-138E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]