PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID evm.model.supercontig_160.33
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Caricaceae; Carica
Family AP2
Protein Properties Length: 688aa    MW: 75397.4 Da    PI: 6.9764
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
evm.model.supercontig_160.33genomeASGPBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP238.92.1e-12329385155
                           AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng.krkrfslgkfgtaeeAakaaiaarkkleg 55 
                                   s+y+GV++++++gr++A+++d  ++  g  rk  + g ++ +e+Aa+a++ a++k++g
  evm.model.supercontig_160.33 329 SQYRGVTRHRWTGRYEAHLWDnSCKkEGqTRKGRQ-GGYDMEEKAARAYDLAALKYWG 385
                                   78*******************77776664346655.77******************98 PP

2AP245.61.8e-14430479355
                           AP2   3 ykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                                   y+GV+++++ grW A+I  +     +k  +lg+f t eeAa+a++ a+ k++g
  evm.model.supercontig_160.33 430 YRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFSTQEEAAEAYDIAAIKFRG 479
                                   9***************988532...5************************997 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541716.08E-14329394IPR016177DNA-binding domain
CDDcd000183.44E-18329392No hitNo description
PfamPF008471.2E-9329385IPR001471AP2/ERF domain
PROSITE profilePS5103216.937330393IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.108.8E-12330393IPR001471AP2/ERF domain
SMARTSM003809.3E-21330399IPR001471AP2/ERF domain
PRINTSPR003675.5E-6331342IPR001471AP2/ERF domain
SuperFamilySSF541712.29E-17428488IPR016177DNA-binding domain
CDDcd000181.50E-24428489No hitNo description
PROSITE profilePS5103219.177429487IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.105.6E-18429487IPR001471AP2/ERF domain
SMARTSM003801.2E-33429493IPR001471AP2/ERF domain
PfamPF008473.0E-9430479IPR001471AP2/ERF domain
PRINTSPR003675.5E-6469489IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0007276Biological Processgamete generation
GO:0010492Biological Processmaintenance of shoot apical meristem identity
GO:0042127Biological Processregulation of cell proliferation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 688 aa     Download sequence    Send to blast
MKTMNDGNNG SNSNHSSWLG FSLSPHMKME IPSDPHHHHH HQFQQQAQPS ATSPAVSNSV  60
PTTFYLSSSQ LNTSALCYNV GENGGFHSPL SVMPLKSDGS LCIMEALTRS HTGGMVACSS  120
PKLEDFLGGA TMETHQYGGN GRETMALSLD SMYYHHQNPD QPEANRPHSL DLLQDFSVQT  180
HHGYYPGLGC HPMYQTPLEE ENKDTQIADC DSQIPQMAED SIPCLKNWVA RHYSPHNAAM  240
EPQVNTSMVD DGGASGSVGA MGCGDLQSLS LSMSPGSQSS CVTALRQISP AGGGESVPLE  300
TKKRSSNGKV GQKQPVHRKS IDTFGQRTSQ YRGVTRHRWT GRYEAHLWDN SCKKEGQTRK  360
GRQGGYDMEE KAARAYDLAA LKYWGPSTHI NFSLENYRQE LEDMKNMSRQ EYVAHLRRKS  420
SGFSRGASMY RGVTRHHQHG RWQARIGRVA GNKDLYLGTF STQEEAAEAY DIAAIKFRGV  480
NAVTNFDITR YDVEKIMASN TLLAGELARR NKKPEATNEA IDYSNNQSVT PNSEEEAIQA  540
AAEDNGNGSD WKMALYQSPP QHQQQPNAVE SLDHDHHAKT VGIVSYRNQT NATFSMALQN  600
LIGTDSGTPT GQMVDECAKI GRHFSNPSSL VTSLNNSREG SPEKSGSGML FAKPPSVSWF  660
PSAAQLRPAA AAISMAHLPL FAAWNDT*
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269|PubMed:10528263, ECO:0000269|PubMed:10639184, ECO:0000269|PubMed:10948255, ECO:0000269|PubMed:11041883, ECO:0000269|PubMed:12183381, ECO:0000269|PubMed:12271029, ECO:0000269|PubMed:12655002, ECO:0000269|PubMed:8742706, ECO:0000269|PubMed:8742707, ECO:0000269|PubMed:9001406, ECO:0000269|PubMed:9093862, ECO:0000269|PubMed:9118807}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00088SELEXTransfer from AT4G37750Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapevm.model.supercontig_160.33
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021888829.10.0AP2-like ethylene-responsive transcription factor ANT
SwissprotQ389141e-155ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBLA0A061FFL00.0A0A061FFL0_THECC; Integrase-type DNA-binding superfamily protein
STRINGevm.model.supercontig_160.330.0(Carica papaya)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM31372863
Representative plantOGRP11217209
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G37750.11e-127AP2 family protein
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Horstman A,Willemsen V,Boutilier K,Heidstra R
    AINTEGUMENTA-LIKE proteins: hubs in a plethora of networks.
    Trends Plant Sci., 2014. 19(3): p. 146-57
    [PMID:24280109]
  3. Li C, et al.
    Ectopic expression of a maize hybrid down-regulated gene ZmARF25 decreases organ size by affecting cellular proliferation in Arabidopsis.
    PLoS ONE, 2014. 9(4): p. e94830
    [PMID:24756087]
  4. Wynn AN,Seaman AA,Jones AL,Franks RG
    Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development.
    Front Plant Sci, 2014. 5: p. 130
    [PMID:24778638]
  5. Randall RS, et al.
    AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
    Biol Open, 2015. 4(10): p. 1229-36
    [PMID:26340943]
  6. Meng LS,Wang ZB,Yao SQ,Liu A
    The ARF2-ANT-COR15A gene cascade regulates ABA-signaling-mediated resistance of large seeds to drought in Arabidopsis.
    J. Cell. Sci., 2015. 128(21): p. 3922-32
    [PMID:26395398]
  7. Yamaguchi N,Jeong CW,Nole-Wilson S,Krizek BA,Wagner D
    AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
    Plant Physiol., 2016. 170(1): p. 283-93
    [PMID:26537561]
  8. Krizek BA, et al.
    RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
    Plant Physiol., 2016. 171(3): p. 2069-84
    [PMID:27208279]
  9. Han H,Krizek BA
    AINTEGUMENTA-LIKE6 can functionally replace AINTEGUMENTA but alters Arabidopsis flower development when misexpressed at high levels.
    Plant Mol. Biol., 2016. 92(4-5): p. 597-612
    [PMID:27605095]
  10. Karpinska B,Alomrani SO,Foyer CH
    Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2018.
    [PMID:28808105]
  11. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]