PlantRegMap
Plant Transcription Factor Database
PlantTFDB
v5.0
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID evm.model.supercontig_104.59
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Caricaceae; Carica
Family E2F/DP
Protein Properties Length: 489aa    MW: 53279.3 Da    PI: 6.1909
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
evm.model.supercontig_104.59genomeASGPBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP862.8e-27215280171
                       E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                                   r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  evm.model.supercontig_104.59 215 RYDSSLGLLTKKFINLVKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 280
                                   6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.2E-29212282IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467856.8E-17215278IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.9E-35215280IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.4E-24217280IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.71E-13295346No hitNo description
PfamPF164212.9E-15295344IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 489 aa     Download sequence    Send to blast
MSSGARASSR PHPPPHPPSS SAAPAAATVV PPIRRHLAFA STKPPFVPPN DYHRFSPSPA  60
SNNNNICSMN TRRVVDREAD AVVFRSPVEC FLDLLLLWFC LDQRDGFIVI LSVFGYWNLC  120
PIRFYLVLVS NFIPPIIWHL QIKRKTATSE NEVEASGCAS PGLTNISNSP FKTPVATKGR  180
ANNRSRASKS NRSAPQTPVS NAGSPAPLTP AGSCRYDSSL GLLTKKFINL VKHAEDGILD  240
LNKAAETLEV QKRRIYDITN VLEGIGLIEK KLKNRIRWKG LDAAKPGEVD GDACILQNET  300
LIAIKAPHGT TLEVPDPDEA VDYPQRRYRI ILRSTMGPID VYLVSQFEEK FEEMNGMEPR  360
ASCQLASSSG SNENQVMEML TLDSPGKELD AQASQTQPMC SDINASQEFA GGIMKITPSD  420
VDNDADYWLL SEADVSITNM WKTDSGMEWA GVNVLSDFGL ADVSSPRPQT PPNATVEVPS  480
ATLNSSAR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A5e-24210281274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapevm.model.supercontig_104.59
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021892443.10.0transcription factor E2FA
SwissprotQ9FNY01e-140E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2P5Y1W50.0A0A2P5Y1W5_GOSBA; Uncharacterized protein
STRINGevm.model.supercontig_104.590.0(Carica papaya)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.21e-121E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]