PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MELO3C024578P1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family E2F/DP
Protein Properties Length: 356aa    MW: 39872.8 Da    PI: 4.6901
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MELO3C024578P1genomeMELONOMICSView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP81.76.4e-2670135171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++++gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn i wkg
  MELO3C024578P1  70 RYDSSLGLLTKKFINLIKQARDGILDLNKAAETL---QV--QKRRIYDITNVLEGIGLIEKKLKNIIYWKG 135
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.5E-2867137IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.1E-3170135IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.65E-1770133IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.7E-2372135IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440741.07E-32149252No hitNo description
PfamPF164219.7E-32151250IPR032198E2F transcription factor, CC-MB domain
CDDcd146607.87E-45151252No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 356 aa     Download sequence    Send to blast
MYNNVVKSND YIHDEGSSKD ALSCVQTPVS AKGGRAYNKS KTSRKTTSGP QTPISDTSTY  60
SPLTPAGNCR YDSSLGLLTK KFINLIKQAR DGILDLNKAA ETLQVQKRRI YDITNVLEGI  120
GLIEKKLKNI IYWKGFNQQI PGNVDSDASM LQVDVENLSF EERRLDDKIR AMQERLRNLS  180
EDENIQKWLF VTEDDIKNLP CFQNETLIAI KAPHGTTLEV PDPDEAVDYP QRRYRIVLRS  240
TMGPIDVYLV SQFEEKFEEM NVVQPPSSFL HASSSGSNEH LATEAIIGES SRNEIEPLAH  300
LSQHSSSCDV NGSNEFPGGM MKILPSDIDN DADYWLLSDA EVSITDMWRT DCILI*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-2462135273PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818761e-129LN681876.1 Cucumis melo genomic scaffold, anchoredscaffold00068.
GenBankLN7132621e-129LN713262.1 Cucumis melo genomic chromosome, chr_8.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016902873.10.0PREDICTED: transcription factor E2FA-like isoform X2
SwissprotQ9FNY01e-135E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A1S4E3R80.0A0A1S4E3R8_CUCME; transcription factor E2FA-like isoform X2
STRINGXP_008462611.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-139E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]