PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MELO3C020321P1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family HD-ZIP
Protein Properties Length: 681aa    MW: 76001.6 Da    PI: 6.6655
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MELO3C020321P1genomeMELONOMICSView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox60.62.4e-192883156
                    TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
        Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                    +++ ++++++q+++Le++F+++++p++++r++L+++lgL+++q+k+WFqN+R++ k
  MELO3C020321P1 28 KKTYHRHNPYQIQQLESFFRQCPHPDENQRRQLSRELGLETKQIKFWFQNKRTQTK 83
                    688999**********************************************9987 PP

2START135.36.4e-432304476206
                     HHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS............SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEE CS
           START   6 aaqelvkkalaeepgWvkss....esengdevlqkfeeskv...........dsgealrasgvvdmvlallveellddkeqWdetla....kaet 81 
                      ++el+++   +ep+W+k        + +d + +                   ++e ++asgvv+m + +lv  +ld   +W   +      aet
  MELO3C020321P1 230 GLEELIRLLRIDEPLWMKTLndgrYVLHRDSYEK------IfprpnhfktssARTESSKASGVVTMSAIQLVDCFLDAD-KWADLFStiitNAET 317
                     57899***************54444444555555......4455555999999**************************.77777777777**** PP

                     EEEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE- CS
           START  82 levissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwveh 169
                        i++g      galqlm++++   splv+ Rdf f+R+++q + g+wvivdvS +  ++  +   ++R+ +lpSg+li++++ng skvtwveh
  MELO3C020321P1 318 FHIIDPGmpgnrsGALQLMYQQMHIFSPLVSpRDFCFLRHCQQIEFGVWVIVDVSYEILKDCVT---SARCWRLPSGCLIQEMPNGCSKVTWVEH 409
                     ****************************9999************************98888775...8*************************** PP

                     EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
           START 170 vdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                     v++++++  h l+r lv ++la ga +w+ tlqr ce+
  MELO3C020321P1 410 VEVDDKTQtHRLYRDLVFNTLAYGADRWLFTLQRMCER 447
                     *****9998***************************97 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.601.0E-201379IPR009057Homeodomain-like
SuperFamilySSF466894.09E-191386IPR009057Homeodomain-like
PROSITE profilePS5007116.7142585IPR001356Homeobox domain
SMARTSM003891.4E-162789IPR001356Homeobox domain
CDDcd000868.87E-172886No hitNo description
PfamPF000466.8E-172883IPR001356Homeobox domain
PROSITE patternPS0002706083IPR017970Homeobox, conserved site
PROSITE profilePS5084843.397216450IPR002913START domain
SuperFamilySSF559611.03E-31219449No hitNo description
CDDcd088753.44E-105221446No hitNo description
SMARTSM002343.0E-29225447IPR002913START domain
PfamPF018521.0E-35230447IPR002913START domain
Gene3DG3DSA:3.30.530.203.8E-11270411IPR023393START-like domain
SuperFamilySSF559611.03E-8468614No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008289Molecular Functionlipid binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 681 aa     Download sequence    Send to blast
MDIMMDGRGG YGGGSPDEQE GSNDRKGKKT YHRHNPYQIQ QLESFFRQCP HPDENQRRQL  60
SRELGLETKQ IKFWFQNKRT QTKAQNERAD NSSLRTENEK IQCENLAIRE ALRNVICPSC  120
GGPPFGEEER QRNLQKLRLE NSHLKEEHEK VSNLLAKYIG KPISQLESLL PVLGSSLDLS  180
PRSSLTQIVP SPAVDLISDP VILDGAATTY QSRGINDLEN ALMLETAATG LEELIRLLRI  240
DEPLWMKTLN DGRYVLHRDS YEKIFPRPNH FKTSSARTES SKASGVVTMS AIQLVDCFLD  300
ADKWADLFST IITNAETFHI IDPGMPGNRS GALQLMYQQM HIFSPLVSPR DFCFLRHCQQ  360
IEFGVWVIVD VSYEILKDCV TSARCWRLPS GCLIQEMPNG CSKVTWVEHV EVDDKTQTHR  420
LYRDLVFNTL AYGADRWLFT LQRMCERLAY TFRDCAPNHE LGGVLTSPEG RRSIMKLSHR  480
MVKNFCGILS MSGKLDFPQL SEVNNSGVRI SVRISSELGQ PSGTVVSAAT SLWLPLQPET  540
IFNFFRDEKA RVQPFIPTEN NMLILQESCI DPLGSLVIYA PIDMPAMNIA TSGQDPSEIP  600
ILPSGFVITG DGRTHSGIGA STSSTLGRPS GSLLTIAFQI LVSSVSSSKQ LNVESVATVN  660
TLISATVQRI KVALNCSCLD *
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818540.0LN681854.1 Cucumis melo genomic scaffold, anchoredscaffold00042.
GenBankLN7132600.0LN713260.1 Cucumis melo genomic chromosome, chr_6.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008457114.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like isoform X2
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A1S3C6250.0A0A1S3C625_CUCME; homeobox-leucine zipper protein HDG11-like isoform X2
STRINGXP_008457113.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF10263398
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]