PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MELO3C001940P1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family HD-ZIP
Protein Properties Length: 706aa    MW: 78420.8 Da    PI: 6.9094
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MELO3C001940P1genomeMELONOMICSView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox61.31.4e-192176156
                    TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
        Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                    +++ ++++++q+++Le++F+++++p++++r +L+++lgL  rq+k+WFqNrR+++k
  MELO3C001940P1 21 KKRYHRHNANQIQRLEAMFKECPHPDEKQRLQLSRELGLAPRQIKFWFQNRRTQMK 76
                    6778999**********************************************998 PP

2START176.12.1e-552194422205
                     HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEE CS
           START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetla....kaetl 82 
                     +a  a++el+++ + +ep+W+ks+    + ++ +++   f++ ++      +++ea+r+sgvv+  +a lv +++d++ +W+e ++     a t+
  MELO3C001940P1 219 IATNAMAELLRLSQTNEPFWMKSPtdgrDLLDLETYEHAFPRPNTplknlhFRTEASRDSGVVIISSAALVDIFMDSN-KWTELFPtivsMARTI 312
                     77899*******************999988888888888988888999******************************.*******999999*** PP

                     EEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-E CS
           START  83 evissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehv 170
                     ev+ssg      g lqlm++elq+lsplvp R f+++Ry++q ++g+w++vdvS + +++++   s   ++++pSg+li++++ng+skvtw+ehv
  MELO3C001940P1 313 EVVSSGmlgsqnGSLQLMYQELQLLSPLVPtRHFYVIRYCQQIEQGVWAVVDVSYNIPRENQI-VSHPQCHRFPSGCLIQDMPNGYSKVTWIEHV 406
                     *************************************************************95.8888999************************ PP

                     E--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXX CS
           START 171 dlkgrlp.hwllrslvksglaegaktwvatlqrqce 205
                     ++++r   hwl+r l++sgla+ga +w+atlqr  e
  MELO3C001940P1 407 EVEDRGStHWLFRDLIHSGLAFGAERWLATLQRMSE 442
                     *****999************************9877 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.604.9E-22672IPR009057Homeodomain-like
SuperFamilySSF466899.19E-20778IPR009057Homeodomain-like
PROSITE profilePS5007117.7671878IPR001356Homeobox domain
SMARTSM003891.5E-181982IPR001356Homeobox domain
CDDcd000863.24E-182079No hitNo description
PfamPF000463.6E-172176IPR001356Homeobox domain
PROSITE patternPS0002705376IPR017970Homeobox, conserved site
PROSITE profilePS5084846.656209446IPR002913START domain
SuperFamilySSF559619.34E-35212444No hitNo description
CDDcd088752.06E-112213442No hitNo description
SMARTSM002343.2E-48218443IPR002913START domain
PfamPF018523.8E-47219442IPR002913START domain
Gene3DG3DSA:3.30.530.209.1E-7278441IPR023393START-like domain
SuperFamilySSF559613.3E-23465697No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 706 aa     Download sequence    Send to blast
MDFGGGSGWD NDSSSDPQRR KKRYHRHNAN QIQRLEAMFK ECPHPDEKQR LQLSRELGLA  60
PRQIKFWFQN RRTQMKAQHE RADNSALRAE NDKIRCENIA IREALKNVIC PSCGGPPLQD  120
PYFDEHKLRI ENAHLKEELD RVSSIAAKYI GRPISQLPPI QPSHFSSLEL SMGSFPSQEM  180
GCPSLDLDLL SASSTSVPNL PYHHPIHLSS VDKSLMTEIA TNAMAELLRL SQTNEPFWMK  240
SPTDGRDLLD LETYEHAFPR PNTPLKNLHF RTEASRDSGV VIISSAALVD IFMDSNKWTE  300
LFPTIVSMAR TIEVVSSGML GSQNGSLQLM YQELQLLSPL VPTRHFYVIR YCQQIEQGVW  360
AVVDVSYNIP RENQIVSHPQ CHRFPSGCLI QDMPNGYSKV TWIEHVEVED RGSTHWLFRD  420
LIHSGLAFGA ERWLATLQRM SERFACLMVT GSSNQDLGGV IPSLEGKRSM MKLAQRMVNN  480
FCASISTSHG HRWTTLSGMN EVGVRVTVHK STDSGQPNGV VLSAATTIWL PVSPQTIFNF  540
FKNDRTRSQW DVLSDGNPVQ EVAHISNGSH PGNCISVLRA FNTSQNNMLI LQESCIDSSG  600
SLVVYCPVDL PAMNVAMSGE DPSSIPLLPS GFTILPDGRR DQGEGASSSS DVHNRSGGSL  660
VTVAFQILVS SLPSGKLNLE SVTTVNNLIS TTVHQIKTAL NCHSS*
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6819320.0LN681932.1 Cucumis melo genomic scaffold, anchoredscaffold00001.
GenBankLN7132660.0LN713266.1 Cucumis melo genomic chromosome, chr_12.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016898817.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A1S4DS380.0A0A1S4DS38_CUCME; homeobox-leucine zipper protein HDG11-like
STRINGXP_008445879.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF10263398
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]